Reference Report

Reference
Citation	Greaves, S., Sanson, B., White, P., Vincent, J.P. (1999). A screen for identifying genes interacting with armadillo, the Drosophila homolog of beta-catenin. Genetics 153(4): 1753--1766. (Export to RIS)
FlyBase ID	FBrf0123026
Publication Type	Research paper
External Crossreferences
PubMed ID	10581282
PubMed Abstract	Drosophila Armadillo is a multifunctional protein implicated in both cell adhesion, as a catenin, and cell signaling, as part of the Wingless signal transduction pathway. We have generated viable fly stocks with alterations in the level of Armadillo available for signaling. Flies from one stock overexpress Armadillo and, as a result, have increased vein material and bristles in the wings. Flies from the other stock have reduced cytoplasmic Armadillo following overexpression of the intracellular domain of DE-cadherin. These flies display a wing-notching phenotype typical of wingless mutations. Both misexpression phenotypes can be dominantly modified by removing one copy of genes known to encode members of the wingless pathway. Here we describe the identification of further mutations that dominantly modify the Armadillo misexpression phenotypes. These mutations are in genes encoding three different functions: establishment and maintenance of adherens junctions, cell cycle control, and Egfr signaling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
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Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (31)
	Df(1)64c18 Df(1)C52 Df(1)HA85 Df(1)JC19 Df(1)RA2 Df(1)v-N48 Df(2L)30A-C Df(2L)ast2 Df(2L)dp-79b Df(2L)ed1 Df(2L)J39 Df(2L)J-H Df(2L)Mdh Df(2L)prd1.7 Df(2L)Prl Df(2L)sc19-8 Df(2L)spd Df(2R)AA21 Df(2R)CX1 Df(2R)en30 Df(2R)Pu-D17 Df(3L)81k19 Df(3L)Ar14-8 Df(3L)Cat Df(3L)pbl-X1 Df(3L)st-f13 Df(3L)vin5 Df(3L)vin7 Df(3R)3450 Df(3R)crb87-5 Df(3R)XTA1
Alleles (35)
	aos::shg^{i.Scer\UAS.T:Hsap\MYC} aos⁰⁰⁶ arm¹ arm² arm^Scer\UAS.cWa arm^{Δα.Scer\UAS} CadN^M19 cdc2^B47 crb¹ CycA³ dlg1¹⁴ ds⁵⁵ dsh³ dsh^b117 Egfr^f3 en^CX1 EP1421^EP1421 Fas3^A183.1F2 ft^G-rv Hsap\JUP^Scer\UAS.cWa kel^DE1 l(2)dC9⁹ l(3)09291⁰⁹²⁹¹ lilli⁰⁰⁶³² nkd² nub^A6 rho¹⁰ Scer\GAL4^en-e16E Scer\GAL4^GMR.PF sdt^EH681 sgg^M11 shg¹ stg² tws⁰¹⁴³⁶ wg^l-17
Constructs (5)
	P{GAL4-ninaE.GMR} P{UAS-arm.W} P{UAS-arm.Δα} P{UAS-Hsap\JUP.W} P{UAS-shg.CADⁱ}
Genes (42)
	aos aos::shg arm bs CadN cdc2 crb CycA dlg1 ds dsh dx Egfr elA elB en EP1421 Fas3 ft Hsap\JUP kel l(2)dC9 l(3)09291 lilli N net nkd nub Px rho sax Scer\GAL4 sd sdt sgg shg stg T:Hsap\MYC tkv tws vg wg
Insertions (4)
	P{en2.4-GAL4}e16E P{EP}EP1421^EP1421 P{UAS-shg.CADⁱ}5 P{UAS-shg.CADⁱ}10