Reference Report

Reference
Citation	Irion, U., Leptin, M. (1999). Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt. Curr. Biol. 9(23): 1373--1381. (Export to RIS)
FlyBase ID	FBrf0123059
Publication Type	Research paper
PubMed ID	10607561
PubMed Abstract	DEAD-box proteins are a large family of proteins found in bacteria, plants and animals, but only few have been analysed functionally. They are involved in the regulation of various aspects of RNA processing and metabolism, including splicing, transport and translation. The study of their function in multicellular organisms has been restricted to a few special cases, such as the Vasa protein in the fruit fly Drosophila.We show that abstrakt, a gene originally identified genetically by its effect on axon outgrowth and fasciculation of the Bolwig nerve, encodes a new Drosophila DEAD-box protein of which the closest homologue is a human gene of unknown function. Using temperature-sensitive alleles to assay its function, we found that abstrakt is essential for survival at all stages throughout the life cycle of the fly. Mutants show specific defects in many developmental processes, including cell-shape changes, localisation of RNA and apoptosis.Abstrakt is not globally required for RNA splicing, transport, subcellular localisation or translation. Nevertheless, there is a widespread requirement for Abstrakt during post-transcriptional gene expression. Abstrakt must affect processing of specific subsets of RNAs, suggesting that differential post-translational control during development is more common than previously suspected.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (1)
	Df(3R)231-5
Alleles (17)
	abs^1B abs^10B abs^14B abs^15B abs^27B abs^29B abs^33B abs^46B abs⁰⁰⁶²⁰ abs⁰⁴⁵⁰⁵ abs^+t5.8 abs^II-F1 abs^P36a abs^Scer\UAS.cIa Ecol\lacZ^A321.3M3 rpr^hs.PW w^+mC
Constructs (3)
	P{abs5.8} P{hs-rpr} P{UAS-abs.I}
Genes (22)
	abs bcd bel crb Dbp73D Dredd Ecol\lacZ futsch Gel His3 hkb insc osk rpr sog stg tub twi vas w βTub56D βTub60D
Insertions (4)
	P{lArB}A321.3M3 P{lArB}abs^P36a P{PZ}abs⁰⁰⁶²⁰ P{PZ}abs⁰⁴⁵⁰⁵