|Citation||Milan, M., Cohen, S.M. (1999). Notch signaling is not sufficient to define the affinity boundary between dorsal and ventral compartments. Mol. Cell 4(6): 1073--1078. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||The developing limbs of Drosophila are subdivided into distinct cells populations known as compartments. Short-range interaction between cells in adjacent compartments induces expression of signaling molecules at the compartment boundaries. In addition to serving as the sources of long-range signals, compartment boundaries prevent mixing of the adjacent cell populations. One model for boundary formation proposes that affinity differences between compartments are defined autonomously as one aspect of compartment-specific cell identity. An alternative is that the affinity boundary depends on signaling between compartments. Here, we present evidence that the dorsal selector gene apterous plays a role in establishing the dorsoventral affinity boundary that is independent of Notch-mediated signaling between dorsal and ventral cells.|
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|Language of Publication||English|
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