Reference Report

Reference
Citation	Renn, S.C., Park, J.H., Rosbash, M., Hall, J.C., Taghert, P.H. (1999). A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell 99(7): 791--802. (Export to RIS)
FlyBase ID	FBrf0123172
Publication Type	Research paper
PubMed ID	10619432
PubMed Abstract	The mechanisms by which circadian pacemaker systems transmit timing information to control behavior are largely unknown. Here, we define two critical features of that mechanism in Drosophila. We first describe animals mutant for the pdf neuropeptide gene, which is expressed by most of the candidate pacemakers (LNv neurons). Next, we describe animals in which pdf neurons were selectively ablated. Both sets of animals produced similar behavioral phenotypes. Both sets entrained to light, but both were largely arrhythmic under constant conditions. A minority of each pdf variant exhibited weak to moderate free-running rhythmicity. These results confirm the assignment of LNv neurons as the principal circadian pacemakers controlling daily locomotion in Drosophila. They also implicate PDF as the principal circadian transmitter.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (3)
	Df(3R)Tl^84cRPA Df(3R)Tl-P Df(3R)Tl-X
Alleles (12)
	BacA\p35^Scer\UAS.cHa disco¹ Ecol\lacZ^Scer\UAS.cUa Pdf⁰¹ Pdf^+t3.530 Pdf^Scer\UAS.cRa per⁰¹ rpr^Scer\UAS.cZa Scer\GAL4^P2.4.Pdf w^+mC w^+mW.hs W^Scer\UAS.cZa
Constructs (7)
	P{Pdf^+t3.530} P{Pdf-GAL4.P2.4} P{UAS-lacZ.U} P{UAS-p35.H} P{UAS-Pdf.R} P{UAS-rpr.Z} P{UAS-W.Z}
Genes (10)
	BacA\p35 disco Ecol\lacZ Fmrf Pdf per rpr Scer\GAL4 w W
Insertions (7)
	P{Pdf^+t3.530}B P{Pdf^+t3.530}F P{Pdf^+t3.530}J P{Pdf^+t3.530}X P{WF6}84 P{WF6}W15 P{WF6}W33
Transcripts (2)
	Ecol\lacZ^Fmrf.WF6RA Scer\GAL4^P2.4.PdfRA