Reference Report

Reference
Citation	Verdu, J., Buratovich, M.A., Wilder, E.L., Birnbaum, M.J. (1999). Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat. Cell Biol. 1(8): 500--506. (Export to RIS)
FlyBase ID	FBrf0123227
Publication Type	Research paper
PubMed ID	10587646
PubMed Abstract	Organismal size is determined by a tightly regulated mechanism that coordinates cell growth, cell proliferation and cell death. The Drosophila insulin receptor/Chico/Dp110 pathway regulates cell and organismal size. Here we show that genetic manipulation of the phosphoinositide-3-OH-kinase-dependent serine/threonine protein kinase Akt (protein kinase B) during development of the Drosophila imaginal disc affects cell and organ size in an autonomous manner. Ectopic expression of Akt does not affect cell-fate determination, apoptosis or proliferation rates in imaginal discs. Thus, Akt appears to stimulate intracellular pathways that specifically regulate cell and compartment size independently of cell proliferation in vivo.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nat. Cell Biol.
Title	Nature Cell Biology
Publication Year	1999-
ISBN/ISSN	1465-7392 1476-4679
Data from Reference
Alleles (16)
	Akt1¹ Akt1^hs.PV Akt1^{hs.T:Uuuu\Myr4} Akt1^K214M.hs Akt1^{Scer\UAS.T:Ivir\HA1} Avic\GFP^{S65T.Scer\UAS.T:SV40\nls2} BacA\p35^GMR.PH Scer\GAL4^71B Scer\GAL4^Act5C.PP Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} w^+mC W^GMR.PG
Constructs (9)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{GAL4-dpp.blk1} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{GMR-hid} P{GMRP35} P{UAS-Akt1.HA} P{UAS-GFP^S65T.nls}
Genes (9)
	Akt1 Avic\GFP BacA\p35 Scer\GAL4 T:Ivir\HA1 T:SV40\nls2 T:Uuuu\Myr4 w W
Insertions (2)
	P{en2.4-GAL4}e16E P{GawB}71B