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Reference Report
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| Citation | Miller, D.T., Read, R., Rusconi, J., Cagan, R.L. (2000). The Drosophila primo locus encodes two low-molecular-weight tyrosine phosphatases. Gene 243(1-2): 1--9. (Export to RIS) | ||
| FlyBase ID | FBrf0125124 | ||
| Publication Type | Research paper | ||
| PubMed ID | 10675607 | ||
| PubMed Abstract | The fine modulation of tyrosine phosphorylation by protein tyrosine phosphatases and protein tyrosine kinases is a key regulatory mechanism for many cell signaling pathways active during development. In a screen for genes with interesting expression patterns in the developing Drosophila pupal retina, we identified a novel pair of protein tyrosine phosphatases that exhibit an expression pattern suggesting a role in multiple steps of Drosophila neurogenesis. Together, these phosphatases define the primo locus. Their sequence is approx. 50% identical to each other and to low-molecular-weight protein tyrosine phosphatases (LMW-PTPs) identified in other species. Little is understood of the biological role of LMW-PTPs, and the powerful tools available in Drosophila should provide important insight into their role in signaling and development. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Gene | ||
| Title | Gene | ||
| Publication Year | 1976- | ||
| ISBN/ISSN | 0378-1119 | ||
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Data from Reference
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| Alleles (1)
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| Genes (4)
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| Insertions (1)
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