|Citation||Miller, D.T., Read, R., Rusconi, J., Cagan, R.L. (2000). The Drosophila primo locus encodes two low-molecular-weight tyrosine phosphatases. Gene 243(1-2): 1--9. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||The fine modulation of tyrosine phosphorylation by protein tyrosine phosphatases and protein tyrosine kinases is a key regulatory mechanism for many cell signaling pathways active during development. In a screen for genes with interesting expression patterns in the developing Drosophila pupal retina, we identified a novel pair of protein tyrosine phosphatases that exhibit an expression pattern suggesting a role in multiple steps of Drosophila neurogenesis. Together, these phosphatases define the primo locus. Their sequence is approx. 50% identical to each other and to low-molecular-weight protein tyrosine phosphatases (LMW-PTPs) identified in other species. Little is understood of the biological role of LMW-PTPs, and the powerful tools available in Drosophila should provide important insight into their role in signaling and development.|
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|Language of Publication||English|
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