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Reference
Citation
Li, L., Vaessin, H. (2000). Pan-neural prospero terminates cell proliferation during Drosophila neurogenesis.  Genes Dev. 14(2): 147--151.
FlyBase ID
FBrf0125193
Publication Type
Research paper
Abstract
Organogenesis requires coordination between developmental specific regulators and genes governing cell proliferation. Here we show that Drosophila prospero encodes a critical regulator of the transition from mitotically active cells to terminal differentiated neurons. Loss of pros results in aberrant expression of multiple cell-cycle regulatory genes and ectopic mitotic activity. In contrast, ectopic pros expression causes transcriptional suppression of multiple cell-cycle regulatory genes and premature termination of cell division. pros activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes.
PubMed ID
PubMed Central ID
PMC316344 (PMC) (EuropePMC)
DOI
Related Publication(s)
Review
Paper alert.
Schuldt, 2000, Curr. Opin. Genet. Dev. 10(2): 135 [FBrf0126744]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (7)
    Genes (18)
    Insertions (2)
    Transgenic Constructs (2)