Reference Report

Reference
Citation	Yu, F., Morin, X., Cai, Y., Yang, X., Chia, W. (2000). Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell 100(4): 399--409. (Export to RIS)
FlyBase ID	FBrf0125333
Publication Type	Research paper
PubMed ID	10693757
PubMed Abstract	Asymmetric localization is a prerequisite for inscuteable (insc) to function in coordinating and mediating asymmetric cell divisions in Drosophila. We show here that Partner of Inscuteable (Pins), a new component of asymmetric divisions, is required for Inscuteable to asymmetrically localize. In the absence of pins, Inscuteable becomes cytoplasmic and asymmetric divisions of neuroblasts and mitotic domain 9 cells show defects reminiscent of insc mutants. Pins colocalizes with Insc and interacts with the region necessary and sufficient for directing its asymmetric localization. Analyses of pins function in neuroblasts reveal two distinct steps for Insc apical cortical localization: A pins-independent, bazooka-dependent initiation step during delamination (interphase) and a later maintenance step during which Baz, Pins, and Insc localization are interdependent.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(2R)P72
Alleles (14)
	baz^unspecified insc^{5'NheI.hs.T:Zzzz\FLAG} insc²² mira^unspecified numb^unspecified pon^unspecified pros^unspecified raps^P17 raps^P62 raps^P89 raps^P120 raps^Scer\UAS.cYa Scer\GAL4^sca-P309 w^+mC
Constructs (2)
	P{hs-insc.5'NheI} P{UAS-pins.Y}
Genes (15)
	baz eve insc mira numb pon pros raps Scer\GAL4 T:Zzzz\FLAG w βTub56D βTub60D βTub85D βTub97EF
Insertions (2)
	P{EP}wdb^EP3559 P{GAL4}sca^P309