Reference Report

Reference
Citation	Kurata, S., Go, M.J., Artavanis-Tsakonas, S., Gehring, W.J. (2000). Notch signaling and the determination of appendage identity. Proc. Natl. Acad. Sci. U.S.A. 97(5): 2117--2122. (Export to RIS)
FlyBase ID	FBrf0126718
Publication Type	Research paper
PubMed ID	10681430
PubMed Abstract	The Notch signaling pathway defines an evolutionarily conserved cell-cell interaction mechanism that throughout development controls the ability of precursor cells to respond to developmental signals. Here we show that Notch signaling regulates the expression of the master control genes eyeless, vestigial, and Distal-less, which in combination with homeotic genes induce the formation of eyes, wings, antennae, and legs. Therefore, Notch is involved in a common regulatory pathway for the determination of the various Drosophila appendages.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (11)
	Antp^Scer\UAS.cBa Ecol\lacZ^Scer\UAS.cUa ey² ey^R ey^Scer\UAS.cHa N^{ECN.Scer\UAS.cGa} N^ICN.Scer\UAS Scer\GAL4^dpp.blk1 Scer\GAL4^ey.PH Su(H)^unspecified toy^Scer\UAS.cCa
Constructs (8)
	P{GAL4-dpp.blk1} P{GAL4-ey.H} P{UAS-Antp.B} P{UAS-ey.H} P{UAS-lacZ.U} P{UAS-N.ECN.G} P{UAS-N.ICN} P{UAS-toy.C}
Genes (8)
	Antp Dll Ecol\lacZ ey N Scer\GAL4 Su(H) toy