Home
Reference Report
| Reference | |||
|---|---|---|---|
| Citation | Wang, J., Tie, F., Jane, E., Schumacher, A., Harte, P.J., Magnuson, T. (2000). Mouse homolog of the Drosophila Pc-G gene esc exerts a dominant negative effect in Drosophila. genesis 26(1): 67--76. (Export to RIS) | ||
| FlyBase ID | FBrf0126722 | ||
| Publication Type | Research paper | ||
| PubMed ID | 10660674 | ||
| PubMed Abstract | The Polycomb group genes are involved in maintaining long term transcriptional repression of the homeotic genes in both Drosophila and mammals. The mouse eed locus encodes the highly conserved ortholog of the Drosophila ESC protein. To test the functional conservation between the two genes, eed was introduced into the fly to determine whether it could rescue the esc mutant phenotype. eed exerted a dominant negative effect on the leg transformation phenotype associated with the esc mutation. This result is interpreted in light of in vitro protein-protein binding data and in vivo polytene chromosome staining indicating the lack of significant interaction between Eed and fly E(Z), a molecular partner of ESC. genesis 26:67-76, 2000 | ||
| DOI | |||
| Related Publication(s) | |||
Recent Updates
|
|||
| Description |
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
|
||
| Update Feed |
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
|
||
| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
|
Associated Information
|
|||
| Comments | |||
| Associated Files | |||
|
Other Information
|
|||
| Secondary IDs | |||
| Language of Publication | English | ||
| Additional Languages of Abstract | |||
| Also Published As | |||
|
Parent Publication
|
|||
| Publication Type | Journal | ||
| Abbreviation | genesis | ||
| Title | genesis | ||
| Publication Year | 2000- | ||
| ISBN/ISSN | 1526-954X 1526-968X | ||
|
Data from Reference
|
|||
| Alleles (5)
|
|||
| Constructs (2)
|
|||
| Genes (3)
|
|||