Reference Report

Reference
Citation	Blaumueller, C.M., Mlodzik, M. (2000). The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development. Mech. Dev. 92(2): 251--262. (Export to RIS)
FlyBase ID	FBrf0127012
Publication Type	Research paper
PubMed ID	10727863
PubMed Abstract	The Drosophila expanded (ex) gene encodes a protein thought to play a role in signaling at apical junctions of epithelial cells. Previous studies have characterized this gene as a tumor suppressor involved in regulating the growth of a subset of Drosophila imaginal discs (Boedigheimer, M., Laughon, A., 1993. expanded: a gene involved in the control of cell proliferation in imaginal discs, Development 118, 1291-1301); although ex negatively regulates cell proliferation in the developing wing, it appeared to have a conflicting role in the eye. In contrast, our analysis of the loss-of-function phenotype indicates that ex does, in fact, regulate growth in the eye. We also show that this gene plays a role in patterning of the eye, mainly at the level of planar polarity. Our studies further demonstrate that, contrary to what was expected based on loss-of-function data, the tissue reduction phenotypes resulting from Ex overexpression are attributable to the induction of apoptotic cell death. Taken together, our data suggest that Ex is a versatile molecule that plays a role in most of the processes that govern disc development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (15)
	BacA\p35^Scer\UAS.cHa dsh^hs.sev.B Ecol\lacZ^svp-07842 ex⁰¹²⁷⁰ ex^e1 ex^Scer\UAS.cBa fz^hs.sev Rac1^V12.hs.sev Rho1^V14.sev Scer\GAL4^32B Scer\GAL4^bi-omb-Gal4 Scer\GAL4^Bx-MS1096 Scer\GAL4^ey.PH Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev
Constructs (11)
	P{ex} P{exC} P{ey-GAL4.S} P{GAL4-ey.H} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{sE-Dsh.B} P{sE-Rac1.V12} P{sE-Rho1.V14} P{sev-fz.T} P{UAS-p35.H}
Genes (13)
	BacA\p35 ct dsh Ecol\lacZ elav ex fz N Rac1 Rho1 salm Scer\GAL4 svp
Insertions (5)
	P{GAL4}bi^omb-Gal4 P{GawB}32B P{GawB}Bx^MS1096 P{PZ}ex⁰¹²⁷⁰ P{PZ}svp⁰⁷⁸⁴²