Reference Report

Reference
Citation	Cadavid, A.L., Ginzel, A., Fischer, J.A. (2000). The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis. Development 127(8): 1727--1736. (Export to RIS)
FlyBase ID	FBrf0127031
Publication Type	Research paper
PubMed ID	10725248
PubMed Abstract	Fat facets is a deubiquitinating enzyme required in a cell communication pathway that limits to eight the number of photoreceptor cells in each facet of the Drososphila compound eye. Genetic data support a model whereby Faf removes ubiquitin, a polypeptide tag for protein degradation, from a specific ubiquitinated protein thus preventing its degradation. Here, mutations in the liquid facets gene were identified as dominant enhancers of the fat facets mutant eye phenotype. The liquid facets locus encodes epsin, a vertebrate protein associated with the clathrin endocytosis complex. The results of genetic experiments reveal that fat facets and liquid facets facilitate endocytosis and function in common cells to generate an inhibitory signal that prevents ectopic photoreceptor determination. Moreover, it is demonstrated that the fat facets mutant phenotype is extraordinarily sensitive to the level of liquid facets expression. We propose that Liquid facets is a candidate for the critical substrate of Fat facets in the eye.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(3L)lqf-cE278 Df(3L)pbl-X1 In(3L)lqf^AG
Alleles (26)
	AP-2α³ Chc¹ Chc⁴ eff⁰¹⁴⁶² eff^XS347 faf^BX3 faf^BX4 faf^FO8 faf^unspecified lqf^+t19G lqf^AG lqf^ARI lqf^bE25 lqf^bE248 lqf^BT lqf^FDD9 lqf^{ro.T:Zzzz\FLAG} lqf^S011027 Prosβ6¹ Prosβ6^rv10e shi¹ shi² shi^EM42 shi^EM45 w^+* w^+mC
Constructs (2)
	P{lqf⁺19G} P{ro-lqf.FLAG}
Genes (9)
	AP-2α Chc eff faf lqf Prosβ6 shi T:Zzzz\FLAG w
Insertions (3)
	P{lacW}l(3)s5277^s5277 P{lacW}lqf^S011027 P{lacW}smid^j8A6