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| Citation | Davis, T., Kurihara, J., Yamamoto, D. (2000). Genomic organisation and characterisation of the neural sex-determination gene fruitless (fru) in the Hawaiian species Drosophila heteroneura. Gene 246(1-2): 143--149. (Export to RIS) | ||
| FlyBase ID | FBrf0127049 | ||
| Publication Type | Research paper | ||
| PubMed ID | 10767535 | ||
| PubMed Abstract | There are several mechanisms for the determination of sex. Sexual behaviour is part of the sex-determination cascade, and in Drosophila melanogaster male courtship is controlled in part by the fruitless gene. As part of a study of sexual behaviour in Hawaiian Drosophila, we have cloned the neural sex-determination gene fru from the Hawaiian picture-wing species Drosophila heteroneura. The fru gene has at least seven exons covering a region of 18kb and encodes three transcripts, fruA, fruB and fruC. Each transcript encodes a single ORF of 841, 678 and 691aa, respectively. The FRUA and FRUB proteins have a BTB protein-protein-binding domain and two zinc finger-like domains and are well conserved with the D. melanogaster proteins. The FRUC protein has a BTB domain but no zinc finger-like domains. The fru gene is expressed in 1-7 day old adult males as a 5.1kb transcript. This transcript is not seen in adult females, so the fru gene has a different pattern of sex-differential expression in the Hawaiian Drosophila compared with D. melanogaster. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Gene | ||
| Title | Gene | ||
| Publication Year | 1976- | ||
| ISBN/ISSN | 0378-1119 | ||
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Data from Reference
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| Genes (2)
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