|Citation||Henikoff, J.G., Henikoff, S. (2000). Drosophila genomic sequence annotation using the BLOCKS+ database. Genome Res. 10(4): 543--546. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||A simple and general homology-based method for gene finding was applied to the 2.9-Mb Drosophila melanogaster Adh region, the target sequence of the Genome Annotation Assessment Project (GASP). Each strand of the entire sequence was used as query of the BLOCKS+ database of conserved regions of proteins. This led to functional assignments for more than one-third of the genes and two-thirds of the transposons. Considering the enormous size of the query, the fact that only two false-positive matches were reported emphasizes the high selectivity of protein family-based methods for gene finding. We used the search results to improve BLOCKS+ by identifying compositionally biased blocks. Our results confirm that protein family databases can be used effectively in automated sequence annotation efforts.|
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|Language of Publication||English|
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