Reference Report

Reference
Citation	Jaw, T.J., You, L., Knoepfler, P.S., Yao, L., Pai, C., Tang, C., Chang, L., Berthelsen, J., Blasi, F., Kamps, M.P., Sun, Y.H. (2000). Direct interaction of two homeoproteins, homothorax and extradenticle, is essential for EXD nuclear localization and function. Mech. Dev. 91(1-2): 279--291. (Export to RIS)
FlyBase ID	FBrf0127140
Publication Type	Research paper
PubMed ID	10704852
PubMed Abstract	The Drosophila Homothorax (HTH) and Extradenticle (EXD) are two homeoproteins required in a number of developmental processes. EXD can function as a cofactor to Hox proteins. Its nuclear localization is dependent on HTH. In this study we present evidence of in vivo physical interaction between HTH and EXD, mediated primarily through an evolutionarily conserved MH domain in HTH. This interaction is essential for the mutual stabilization of both proteins, for EXD nuclear localization, and for the cooperative DNA binding of the EXD-HTH heterodimer. Some in vivo functions require both EXD and HTH in the nucleus, suggesting that the EXD-HTH complex may function as a transcriptional regulator.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Alleles (15)
	Ecol\lacZ^{hth-dtl-S142204} exd¹ exd^{Scer\UAS.NLS.T:Zzzz\FLAG} Hsap\PKNOX1^Scer\UAS.cJa hth^{IL:AA.Scer\UAS} hth^KI.Scer\UAS hth^{KΔHD.Scer\UAS} hth^Scer\UAS.cPa hth^{Scer\UAS.KRDK} hth^{ΔHD.Scer\UAS} hth^{ΔMH.Scer\UAS} Scer\GAL4^B19 Scer\GAL4^dpp.blk1 Scer\GAL4^GMR.PF w^+mC
Constructs (12)
	P{B19-GAL4} P{GAL4-dpp.blk1} P{GAL4-ninaE.GMR} P{UAS-hth.IL/AA} P{UAS-hth.KI} P{UAS-hth.KRDK} P{UAS-hth.KΔHD} P{UAS-hth.P} P{UAS-hth.ΔHD} P{UAS-hth.ΔMH} P{UAS-NLS-exd} P{UAS-PKNOX1}
Genes (7)
	Ecol\lacZ exd Hsap\PKNOX1 hth Scer\GAL4 T:Zzzz\FLAG w
Insertions (1)
	P{lacW}hth^dtl-S142204