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Citation
Lloyd, T.E., Verstreken, P., Ostrin, E.J., Phillippi, A., Lichtarge, O., Bellen, H.J. (2000). A genome-wide search for synaptic vesicle cycle proteins in Drosophila.  Neuron 26(1): 45--50.
FlyBase ID
FBrf0127207
Publication Type
Research paper
Abstract
The recent completion of the Drosophila genome sequence opens new avenues for neurobiology research. We screened the fly genome sequence for homologs of mammalian genes implicated directly or indirectly in exocytosis and endocytosis of synaptic vesicles. We identified fly homologs for 93% of the vertebrate genes that were screened. These are on average 60% identical and 74% similar to their vertebrate counterparts. This high degree of conservation suggests that little protein diversification has been tolerated in the evolution of synaptic transmission. Finally, and perhaps most exciting for Drosophila neurobiologists, the genomic sequence allows us to identify P element transposon insertions in or near genes, thereby allowing rapid isolation of mutations in genes of interest. Analysis of the phenotypes of these mutants should accelerate our understanding of the role of numerous proteins implicated in synaptic transmission.
PubMed ID
PubMed Central ID
Related Publication(s)
Personal communication to FlyBase
New genes and synaptic vesicle cycle proteins.
Verstreken and Bellen, 2000.9.4, New genes and synaptic vesicle cycle proteins. [FBrf0131218]
Associated Information
Comments
FlyBase curator comment: Table 1 mentions 'VAP-33-2', stating that this gene is localized to 101F-102F, but subsequent papers from the same group show this is a mistake (e.g. FBrf0151448, FBrf0202930). The 'Vap-33-2' Gene Report has now been removed from FlyBase.
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Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference