A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

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Citation Price, D., Rabinovitch, S., O'Farrell, P.H., Campbell, S.D. (2000). Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis.  Genetics 155(1): 159--166.
FlyBase ID FBrf0127282
Type of publication Research paper
Offprint Available Yes
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PubMed ID 10790391
PubMed Abstract In Drosophila, the maternally expressed mei-41 and grp genes are required for successful execution of the nuclear division cycles of early embryogenesis. In fission yeast, genes encoding similar kinases (rad3 and chk1, respectively) are components of a cell cycle checkpoint that delays mitosis by inhibitory phosphorylation of Cdk1. We have identified mutations in a gene encoding a Cdk1 inhibitory kinase, Drosophila wee1 (Dwee1). Like mei-41 and grp, Dwee1 is zygotically dispensable but is required maternally for completing the embryonic nuclear cycles. The arrest phenotype of Dwee1 mutants, as well as genetic interactions between Dwee1, grp, and mei-41 mutations, suggest that Dwee1 is functioning in the same regulatory pathway as these genes. These findings imply that inhibitory phosphorylation of Cdk1 by Dwee1 is required for proper regulation of the early syncytial cycles of embryogenesis.
Biosis 2000.254324
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Language of publication English
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Abbreviation Genetics
Title Genetics
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Volume range 1-
Year range 1916-
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Place of publication Austin, TX, etc
Language of publication English
ISBN/ISSN 0016-6731
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