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Wallace, K., Liu, T.H., Vaessin, H. (2000). The pan-neural bHLH proteins deadpan and asense regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes.  genesis 26(1): 77--85.
FlyBase ID
FBrf0127379
Publication Type
Research paper
Abstract

Developmental regulators and cell cycle regulators have to interface in order to ensure appropriate cell proliferation during organogenesis. Our analysis of the roles of the pan-neural genes deadpan and asense defines critical roles for these genes in regulation of mitotic activities in the larval optic lobes. Loss of deadpan results in reduced cell proliferation, while ectopic deadpan expression causes over-proliferation. In contrast, loss of asense results in increased proliferation, while ectopic asense expression causes reduced proliferation. Consistent with these observations endogenous Deadpan is expressed in mitotic areas of the optic lobes, and endogenous Asense is expressed in cells that will become quiescent. Altered Deadpan or Asense expression results in altered expression of the cyclin dependent kinase inhibitor gene dacapo. Thus, regulation of mitotic activity during optic lobe development may, at least in part, involve deadpan and asense mediated regulation of the cyclin dependent kinase inhibitor gene dacapo. genesis 26:77-85 , 2000.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    genesis
    Title
    genesis
    Publication Year
    2000-
    ISBN/ISSN
    1526-954X 1526-968X
    Data From Reference
    Aberrations (2)
    Alleles (5)
    Genes (5)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (2)