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Zars, T., Wolf, R., Davis, R., Heisenberg, M. (2000). Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram.  Learn. Mem. 7(1): 18--31.
FlyBase ID
FBrf0127414
Publication Type
Research paper
Abstract

Most attempts to localize physical correlates of memory in the central nervous system (CNS) rely on ablation techniques. This approach has the limitation of defining just one of an unknown number of structures necessary for memory formation. We have used the Drosophila rutabaga type I Ca(2+)/CaM-dependent adenylyl cyclase (AC) gene to determine in which CNS region AC expression is sufficient for memory formation. Using pan-neural and restricted CNS expression with the GAL4 binary transcription activation system, we have rescued the memory defect of the rutabaga mutant in a fast robust spatial learning paradigm. The ventral ganglion, antennal lobes, and median bundle are likely the CNS structures sufficient for rutabaga AC- dependent spatial learning.

PubMed ID
PubMed Central ID
PMC311318 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Learn. Mem.
    Title
    Learning and Memory
    Publication Year
    1994-
    ISBN/ISSN
    1072-0502
    Data From Reference