Reference Report

Reference
Citation	Jinks, T.M., Polydorides, A.D., Calhoun, G., Schedl, P. (2000). The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster. Mol. Cell 5(3): 581--587. (Export to RIS)
FlyBase ID	FBrf0128151
Publication Type	Research paper
PubMed ID	10882142
PubMed Abstract	The choice of sexual identity in Drosophila is determined by a system that measures the X chromosome to autosome ratio (X/A). This system depends upon unequal expression of X-linked numerator genes in 1X and 2X nuclei. The numerators activate a special Sxl promoter, Sxl-Pe, in 2X/2A nuclei, but not 1X/2A nuclei. By multimerizing a conserved Sxl-Pe sequence block, we generated a gain-of-function promoter, Sxl-PeGOF, that is inappropriately active in 1X/2A nuclei. GOF activity requires the X-linked unpaired (upd) gene, which encodes a ligand for the Drosophila JAK/STAT signaling pathway. upd also functions as a numerator element in regulating wild-type Sxl-Pe reporters. We demonstrate that the JAK kinase, Hopscotch, and the STAT DNA-binding protein, Marelle, are also required for Sxl-Pe activation.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Aberrations (1)
	Df(1)N19
Alleles (11)
	Ecol\lacZ^{Sxl.Pe.0.4.GOF} Ecol\lacZ^{Sxl.Pe.0.4.ΔB} Ecol\lacZ^Sxl.Pe.0.4 Ecol\lacZ^Sxl.Pe.1.4 Ecol\lacZ^Sxl.Pe.1.7 Ecol\lacZ^Sxl.Pe.3 hop^Tum os^upd-3 sc^unspecified sisA^unspecified Stat92E^unspecified
Constructs (6)
	P{Sxl-Pe_0.4kb:lacZ} P{Sxl-Pe_0.4kbGOF:lacZ} P{Sxl-Pe_0.4kbΔB:lacZ} P{Sxl-Pe_1.4kb:lacZ} P{Sxl-Pe_1.7kb:lacZ} P{Sxl-Pe_3kb:lacZ}
Genes (6)
	Ecol\lacZ hop os sc sisA Stat92E