Reference Report

Reference
Citation	Abdelilah-Seyfried, S., Chan, Y.M., Zeng, C., Justice, N.J., Younger-Shepherd, S., Sharp, L.E., Barbel, S., Meadows, S.A., Jan, L.Y., Jan, Y.N. (2000). A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics 155(2): 733--752. (Export to RIS)
FlyBase ID	FBrf0128367
Publication Type	Research paper
PubMed ID	10835395
PubMed Abstract	The Drosophila adult external sensory organ, comprising a neuron and its support cells, is derived from a single precursor cell via several asymmetric cell divisions. To identify molecules involved in sensory organ development, we conducted a tissue-specific gain-of-function screen. We screened 2293 independent P-element lines established by P. Rorth and identified 105 lines, carrying insertions at 78 distinct loci, that produced misexpression phenotypes with changes in number, fate, or morphology of cells of the adult external sensory organ. On the basis of the gain-of-function phenotypes of both internal and external support cells, we subdivided the candidate lines into three classes. The first class (52 lines, 40 loci) exhibits partial or complete loss of adult external sensory organs. The second class (38 lines, 28 loci) is associated with increased numbers of entire adult external sensory organs or subsets of sensory organ cells. The third class (15 lines, 10 loci) results in potential cell fate transformations. Genetic and molecular characterization of these candidate lines reveals that some loci identified in this screen correspond to genes known to function in the formation of the peripheral nervous system, such as big brain, extra macrochaetae, and numb. Also emerging from the screen are a large group of previously uncharacterized genes and several known genes that have not yet been implicated in the development of the peripheral nervous system.
DOI
Related Publication(s)
Erratum	A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Abdelilah-Seyfried et al., 2001, Genetics 157(1): 457 [FBrf0132338]
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Alleles (113)
	Adf1^EP815 Amun^EP1503 aop^EP598 aop^EP2500 apt^EP2373 Avic\GFP^Scer\UAS.cUa ban^EP3208 bchs^EP2299 bib^EP2278 bl^EP954 Bx^EP1306 Bx^EP1383 Bx^EP1394 cbt^EP2237 CG4747^EP594 CG5180^EP3073 CG5986^EP3278 CG9932^EP2317 CG12084^EP3673 CG42709^EP3622 Cul-5^EP3390 dally^EP3168 dap^EP2584 dbr^EP456 Ecol\lacZ^neur-A101 Ecol\lacZ^pros-10419 Ef1β^EP2298 Eip75B^EP1121b elB^EP965 elB^EP2039 emc^EP415 emc^EP3620 EP383^EP383 EP566a^EP566a EP566b^EP566b EP595a^EP595a EP595b^EP595b EP596^EP596 EP639^EP639 EP639^EP2148 EP639^EP2402 EP639^EP2437 EP787^EP787 EP1121a^EP1121a EP1216b^EP1216b EP1408^EP1408 EP1523^EP1523 EP1581^EP1581 EP2002b^EP2002b EP2146a^EP2146a EP2409^EP2409 EP2599^EP2599 EP3015a^EP3015a EP3104^EP3104 EP3474^EP3474 EP3707^EP3707 eRF1^EP3121 esg^EP683 esg^EP684 esg^EP2009 esg^EP2159 esg^EP2408 faf^EP381 glec^EP3449 Gli^EP2306 grp^EP587 H^E21 hh^EP3521 Hr4^EP1232 Hrb27C^EP748 insc^EP2010 Kr-h1^EP2289 l(2)k10113^EP1221 lola^EP343 lolal^EP647 Mef2^EP2002a MESR4^EP386 MESR4^EP988 mir-278^EP1229 mir-278^EP2316 N^55e11 Nab2^EP3716 nej^EP1149 nej^EP1179 NFAT^EP1335 nuf^EP3324 nuf^EP3339 numb^EP2542 pain^EP2251 Parg^EP351 pbl^EP3415 ppo^EP2478 pygo^EP1076 qsm^EP2356 Rab11^EP3017 Scer\GAL4^ptc-559.1 Scer\GAL4^sca-109-68 Scer\GAL4^sca-537.4 sd^EP1435 shn^EP2359 SNF4Aγ^EP3015b spen^EP2583 stg^EP1213 stg^EP3261 stg^EP3426 stg^EP3432 tara^EP3463 tou^EP622 trbl^EP3519 twe^EP613 UbcD2^EP2146b vfl^EP1344 wdb^EP3559
Constructs (1)
	P{UAS-GFP.U}
Genes (92)
	Adf1 Amun aop apt Avic\GFP ban bchs bib bl Bx cbt CG4747 CG5180 CG5986 CG9932 CG12084 CG42709 dally dap dbr Ecol\lacZ Ef1β Eip75B elB emc EP383 EP566a EP566b EP595a EP595b EP596 EP639 EP787 EP1121a EP1216b EP1408 EP1523 EP1581 EP2002b EP2146a EP2409 EP2599 EP3015a EP3104 EP3390 EP3474 EP3707 eRF1 esg faf glec Gli grp H hh Hr4 Hrb27C insc Kr-h1 l(2)k10113 lola lolal Mef2 MESR4 mir-278 N Nab2 nej NFAT nuf numb pain Parg pbl ppo pygo qsm Rab11 Scer\GAL4 sd shn sktl SNF4Aγ spen stg tara tou trbl twe UbcD2 vfl wdb
Insertions (116)
	P{EP}Adf1^EP815 P{EP}Amun^EP1503 P{EP}aop^EP598 P{EP}aop^EP2500 P{EP}apt^EP2373 P{EP}ban^EP3208 P{EP}bchs^EP2299 P{EP}bib^EP2278 P{EP}bl^EP954 P{EP}Bx^EP1306 P{EP}Bx^EP1383 P{EP}Bx^EP1394 P{EP}cbt^EP2237 P{EP}CG4747^EP594 P{EP}CG5180^EP3073 P{EP}CG5986^EP3278 P{EP}CG6745^EP595b P{EP}CG9932^EP2317 P{EP}CG12084^EP3673 P{EP}CG42709^EP3622 P{EP}Cul-5^EP3390 P{EP}dally^EP3168 P{EP}dap^EP2584 P{EP}dbr^EP456 P{EP}Ef1β^EP2298 P{EP}Eip75B^EP1121b P{EP}elB^EP965 P{EP}elB^EP2039 P{EP}emc^EP415 P{EP}emc^EP3620 P{EP}EP383^EP383 P{EP}EP566a^EP566a P{EP}EP566b^EP566b P{EP}EP595a^EP595a P{EP}EP596^EP596 P{EP}EP639^EP639 P{EP}EP639^EP2148 P{EP}EP639^EP2402 P{EP}EP639^EP2437 P{EP}EP787^EP787 P{EP}EP1121a^EP1121a P{EP}EP1216b^EP1216b P{EP}EP1408^EP1408 P{EP}EP1523^EP1523 P{EP}EP1581^EP1581 P{EP}EP2002b^EP2002b P{EP}EP2122 P{EP}EP2146a^EP2146a P{EP}EP2409^EP2409 P{EP}EP2599^EP2599 P{EP}EP3015a^EP3015a P{EP}EP3104^EP3104 P{EP}EP3474^EP3474 P{EP}EP3707^EP3707 P{EP}eRF1^EP3121 P{EP}esg^EP683 P{EP}esg^EP684 P{EP}esg^EP2009 P{EP}esg^EP2159 P{EP}esg^EP2408 P{EP}faf^EP381 P{EP}glec^EP3449 P{EP}Gli^EP2306 P{EP}grp^EP587 P{EP}hh^EP3521 P{EP}Hmt4-20^EP1216a P{EP}Hr4^EP1232 P{EP}Hrb27C^EP748 P{EP}insc^EP2010 P{EP}Kr-h1^EP2289 P{EP}l(2)k10113^EP1221 P{EP}lola^EP343 P{EP}lolal^EP647 P{EP}Mef2^EP2002a P{EP}MESR4^EP386 P{EP}MESR4^EP988 P{EP}mir-278^EP1229 P{EP}mir-278^EP2316 P{EP}Nab2^EP3716 P{EP}nej^EP1149 P{EP}nej^EP1179 P{EP}NFAT^EP1335 P{EP}NFAT^EP1508 P{EP}nuf^EP3324 P{EP}nuf^EP3339 P{EP}numb^EP2542 P{EP}pain^EP2251 P{EP}Parg^EP351 P{EP}pbl^EP3415 P{EP}ppo^EP2478 P{EP}pygo^EP1076 P{EP}qsm^EP2356 P{EP}qsm^EP2586 P{EP}qsm^EP2587 P{EP}Rab11^EP3017 P{EP}sd^EP1435 P{EP}shn^EP2359 P{EP}SNF4Aγ^EP3015b P{EP}spen^EP2583 P{EP}stg^EP1213 P{EP}stg^EP3261 P{EP}stg^EP3426 P{EP}stg^EP3432 P{EP}tara^EP3463 P{EP}tou^EP622 P{EP}trbl^EP3519 P{EP}twe^EP613 P{EP}UbcD2^EP2146b P{EP}vfl^EP1344 P{EP}wdb^EP3559 P{GawB}ptc^559.1 P{GawB}sca^109-68 P{GawB}sca^537.4 P{lacW}UbcD2^k13206 P{lArB}neur^A101 P{PZ}pros¹⁰⁴¹⁹