Reference Report

Reference
Citation	Araujo, H., Bier, E. (2000). sog and dpp exert opposing maternal functions to modify Toll signaling and pattern the dorsoventral axis of the Drosophila embryo. Development 127(16): 3631--3644. (Export to RIS)
FlyBase ID	FBrf0128377
Publication Type	Research paper
External Crossreferences
PubMed ID	10903186
PubMed Abstract	The short gastrulation (sog) and decapentaplegic (dpp) genes function antagonistically in the early Drosophila zygote to pattern the dorsoventral (DV) axis of the embryo. This interplay between sog and dpp determines the extent of the neuroectoderm and subdivides the dorsal ectoderm into two territories. Here, we present evidence that sog and dpp also play opposing roles during oogenesis in patterning the DV axis of the embryo. We show that maternally produced Dpp increases levels of the I(kappa)B-related protein Cactus and reduces the magnitude of the nuclear concentration gradient of the NF(kappa)B-related Dorsal protein, and that Sog limits this effect. We present evidence suggesting that Dpp signaling increases Cactus levels by reducing a signal-independent component of Cactus degradation. Epistasis experiments reveal that sog and dpp act downstream of, or in parallel to, the Toll receptor to reduce translocation of Dorsal protein into the nucleus. These results broaden the role previously defined for sog and dpp in establishing the embryonic DV axis and reveal a novel form of crossregulation between the NF(kappa)B and TGF(beta) signaling pathways in pattern formation.
BIOSIS ID	2000.454538
Zoological Record ID
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Editors
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Dp(1;Y)B^Ssog⁺y⁺ Dp(2;1)G146 In(2LR)O
Alleles (18)
	cact^SA4 cact^ΔPEST.cRa dl¹ dl¹⁵ dpp^BP.hs dpp^Scer\UAS.cHa gd² gd⁷ grk^unspecified Scer\GAL4^55B Scer\GAL4^CY2 Scer\GAL4^e22c sog⁶ sog^hs.PY sog^P1 sog^Scer\UAS.cYa sog^U2 Tl³
Balancers (1)
	CyO-P20
Constructs (4)
	P{hs-dpp.BP} P{HS-sog} P{UAS-dpp.H} P{UAS-sog.Y}
Genes (8)
	cact dl dpp gd grk Scer\GAL4 sog Tl
Insertions (3)
	P{en2.4-GAL4}e22c P{GawB}CY2 P{GawB}Eip63F-1^55B
Transcripts (4)
	sim-XR sna-XR sog-XR vnd-XR