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Citation
Bilder, D., Li, M., Perrimon, N. (2000). Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.  Science 289(5476): 113--116.
FlyBase ID
FBrf0128403
Publication Type
Research paper
Abstract

Loss of cell polarity and tissue architecture are characteristics of malignant cancers derived from epithelial tissues. We provide evidence from Drosophila that a group of membrane-associated proteins act in concert to regulate both epithelial structure and cell proliferation. Scribble (Scrib) is a cell junction-localized protein required for polarization of embryonic and, as demonstrated here, imaginal disc and follicular epithelia. We show that the tumor suppressors lethal giant larvae (lgl) and discs-large (dlg) have identical effects on all three epithelia, and that scrib also acts as a tumor suppressor. Scrib and Dlg colocalize and overlap with Lgl in epithelia; activity of all three genes is required for cortical localization of Lgl and junctional localization of Scrib and Dlg. scrib, dlg, and lgl show strong genetic interactions. Our data indicate that the three tumor suppressors act together in a common pathway to regulate cell polarity and growth control.

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Note

Cell biology. Travel bulletin--traffic jams cause tumors.
Peifer, 2000, Science 289(5476): 67--69 [FBrf0130017]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Alleles (9)
    Genes (6)
    Human Disease Models (1)
    Transgenic Constructs (1)