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Citation
Emery, P., Stanewsky, R., Helfrich-Forster, C., Emery-Le, M., Hall, J.C., Rosbash, M. (2000). Drosophila CRY is a deep brain circadian photoreceptor.  Neuron 26(2): 493--504.
FlyBase ID
FBrf0128455
Publication Type
Research paper
Abstract

cry (cryptochrome) is an important clock gene, and recent data indicate that it encodes a critical circadian photoreceptor in Drosophila. A mutant allele, cry(b), inhibits circadian photoresponses. Restricting CRY expression to specific fly tissues shows that CRY expression is needed in a cell-autonomous fashion for oscillators present in different locations. CRY overexpression in brain pacemaker cells increases behavioral photosensitivity, and this restricted CRY expression also rescues all circadian defects of cry(b) behavior. As wild-type pacemaker neurons express CRY, the results indicate that they make a striking contribution to all aspects of behavioral circadian rhythms and are directly light responsive. These brain neurons therefore contain an identified deep brain photoreceptor, as well as the other circadian elements: a central pace-maker and a behavioral output system.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (10)
    Genes (8)
    Sequence Features (1)
    Experimental Tools (2)
    Transgenic Constructs (8)