Reference Report

Reference
Citation	Mata, J., Curado, S., Ephrussi, A., Rorth, P. (2000). Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis. Cell 101(5): 511--522. (Export to RIS)
FlyBase ID	FBrf0128569
Publication Type	Research paper
PubMed ID	10850493
PubMed Abstract	Morphogenesis and cell differentiation in multicellular organisms often require accurate control of cell divisions. We show that a novel cell cycle regulator, tribbles, is critical for this control during Drosophila development. During oogenesis, the level of tribbles affects the number of germ cell divisions as well as oocyte determination. The mesoderm anlage enters mitosis prematurely in tribbles mutant embryos, leading to gastrulation defects. We show that Tribbles acts by specifically inducing degradation of the CDC25 mitotic activators String and Twine via the proteosome pathway. By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination.
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (2)
	Df(3L)rdgC-co2 Df(3L)ri-79c
Alleles (22)
	bam^unspecified CycA^{MtnA.T:Ivir\HA1} CycB^{MtnA.T:Ivir\HA1} Scer\GAL4^32B Scer\GAL4^en-e16E Scer\GAL4^{nos.UTR.T:Hsim\VP16} Scer\UAS^14x.P\T stg^EPg30417 stg^{MtnA.T:Ivir\HA1} stg^Scer\UAS.cNa stg^{Scer\UAS.P\T.cMa} stg^unspecified trbl^+tMa trbl^EP1119 trbl^EP3519 trbl^EPg35131 trbl^{MtnA.T:Ivir\HA1} trbl^Scer\UAS.cMa trbl^{Scer\UAS.P\T.cMa} TrlBR^cRa twe^{MtnA.T:Ivir\HA1} w^+mC
Balancers (1)
	CyO-P{EPg}4-38
Constructs (8)
	P{EPg} P{GAL4::VP16-nos.UTR} P{trbl^+tMa} P{UASp-stg.M} P{UASp-trbl.M} P{UAS-stg.N} P{UAS-trbl.M} pP{EPg}
Genes (14)
	bam CycA CycB grp Scer\GAL4 Scer\UAS sim stg T:Hsim\VP16 T:Ivir\HA1 trbl TrlBR twe w
Insertions (7)
	P{en2.4-GAL4}e16E P{EP}trbl^EP1119 P{EP}trbl^EP3519 P{EPg}4-38 P{EPg}stg^EPg30417 P{EPg}trbl^EPg35131 P{GawB}32B