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Citation
Rutschmann, S., Jung, A.C., Hetru, C., Reichhart, J.M., Hoffmann, J.A., Ferrandon, D. (2000). The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila.  Immunity 12(5): 569--580.
FlyBase ID
FBrf0128630
Publication Type
Research paper
Abstract
We have isolated two Drosophila lines that carry point mutations in the gene coding for the NF-KB-like factor DIF. Like mutants of the Toll pathway, Dif mutant flies are susceptible to fungal but not to bacterial infections. Genetic epistasis experiments demonstrate that Dif mediates the Toll-dependent control of the inducibility of the antifungal peptide gene Drosomycin. Strikingly, DIF alone is required for the antifungal response in adults, but is redundant in larvae with Dorsal, another Rel family member. In Drosophila, Dif appears to be dedicated to the antifungal defense elicited by fungi and gram-positive bacteria. We discuss in this light the possibility that NF-KB1/p50 might be required more specifically in the innate immune response against gram-positive bacteria in mammals.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Immunity
    Title
    Immunity
    Publication Year
    1994-
    ISBN/ISSN
    1074-7613
    Data From Reference
    Aberrations (2)
    Alleles (9)
    Gene Groups (2)
    Genes (14)
    Transgenic Constructs (3)