Reference Report

Reference
Citation	Yang, P., Shaver, S.A., Hilliker, A.J., Sokolowski, M.B. (2000). Abnormal turning behavior in Drosophila larvae. Identification and molecular analysis of scribbler (sbb). Genetics 155(3): 1161--1174. (Export to RIS)
FlyBase ID	FBrf0128690
Publication Type	Research paper
PubMed ID	10880478
PubMed Abstract	Our genetic dissection of behavior has isolated scribbler (sbb), a vital gene that encodes a novel protein expressed in the embryonic and larval nervous systems and in the imaginal discs. Larvae with mutations in sbb exhibit abnormally high amounts of turning behavior in the absence of food. sbb is a large gene spanning >50 kb of genomic DNA with four major developmentally regulated transcripts. Transgenic rescue of scribbler behavior was demonstrated by targeting expression of a normal sbb transgene (sbb(+)) expressing one of the major transcripts to the nervous system. The vital function of sbb was restored by ubiquitous expression of this transgene throughout development.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (1)
	Df(2R)PC4
Alleles (18)
	for^R for^s sbb⁰³⁴³² sbb⁰⁴⁴⁴⁰ sbb⁰⁴⁵²⁵ sbb^EP328 sbb^hs.PY sbb^J6 sbb^J9 sbb^J10 sbb^J12 sbb^J13 sbb^J17 sbb^k00702 sbb^Scer\UAS.cYa Scer\GAL4^elav-C155 Scer\GAL4^hs.PB w^+mC
Constructs (3)
	P{GAL4-Hsp70.PB} P{hs-sbb.Y} P{UAS-sbb.Y}
Genes (4)
	for sbb Scer\GAL4 w
Insertions (10)
	P{EP}sbb^EP328 P{GawB}elav^C155 P{hs-sbb.Y}1 P{hs-sbb.Y}3 P{lacW}sbb^k00702 P{PZ}sbb⁰³⁴³² P{PZ}sbb⁰⁴⁴⁴⁰ P{PZ}sbb⁰⁴⁵²⁵ P{UAS-sbb.Y}1 P{UAS-sbb.Y}3