|
Reference
|
| Citation |
Sigrist, S.J., Thiel, P.R., Reiff, D.F., Lachance, P.E.D., Lasko, P., Schuster, C.M. (2000). Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Nature 405(6790): 1062--1065. |
| FlyBase ID |
FBrf0128816 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
|
External Crossreferences
|
| PubMed ID |
10890448 |
| PubMed Abstract |
Long-term synaptic plasticity may be associated with structural rearrangements within the neuronal circuitry. Although the
molecular mechanisms governing such activity-controlled morphological alterations are mostly elusive, polysomal accumulations
at the base of developing dendritic spines and the activity-induced synthesis of synaptic components suggest that localized
translation is involved during synaptic plasticity. Here we show that large aggregates of translational components as well
as messenger RNA of the postsynaptic glutamate receptor subunit DGluR-IIA are localized within subsynaptic compartments of
larval neuromuscular junctions of Drosophila melanogaster. Genetic models of junctional plasticity and genetic manipulations
using the translation initiation factors eIF4E and poly(A)-binding protein showed an increased occurrence of subsynaptic translation
aggregates. This was associated with a significant increase in the postsynaptic DGluR-IIA protein levels and a reduction in
the junctional expression of the cell-adhesion molecule Fasciclin II. In addition, the efficacy of junctional neurotransmission
and the size of larval neuromuscular junctions were significantly increased. Our results therefore provide evidence for a
postsynaptic translational control of long-term junctional plasticity.
|
| Biosis |
2000.404099 |
| Zoological record |
|
Associated Information
|
| Comments |
|
| Text of personal communication |
|
| Associated files |
|
Related Publications
|
|
|
Also Published As
|
|
|
Other Reference Information
|
| Secondary IDs |
|
| Language of publication |
English |
| Additional language(s) of abstract |
|
| ISBN |
|
| Place of publication |
|
Published In
|
| Abbreviation |
Nature |
| Title |
Nature |
| Authors |
|
| Volume range |
1- |
| Year range |
1869- |
| Page range |
|
| Publisher |
|
| Place of publication |
London |
| Language of publication |
English |
| ISBN/ISSN |
0028-0836 |
| CODEN |
NATUAS |
Data from Reference
|
Aberrations (2)
|
|
|
Alleles (15)
|
|
|
Constructs (4)
|
|
|
Genes (15)
|
|
|
Insertions (2)
|
|
|
|