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Reference
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| Citation |
Agudo, M., Abad, J.P., Molina, I., Losada, A., Ripoll, P., Villasante, A. (2000). A dicentric chromosome of Drosophila melanogaster showing alternate centromere inactivation. Chromosoma 109(3): 190--196. |
| FlyBase ID |
FBrf0128883 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
10929197 |
| PubMed Abstract |
Dicentric chromosomes are rarely found, because they interfere with normal cell division causing chromosome instability. By
in situ hybridization of region-specific heterochromatic yeast artificial chromosomes we have found that the artificially
generated C(1)A chromosome of Drosophila melanogaster has two potential centromeres: one carries all the sequences of the
centromere of the Y chromosome and the other carries only a part of the Y centromeric region that is rich in telomere-related
sequences. Immunostaining with anti-Bub1 (a kinetochore-specific marker) shows that, in spite of the differences in sequence,
both centromeres can be active although as a rule only one at a time. In a small fraction of the chromosomes centromere inactivation
is incomplete, giving rise to true dicentric chromosomes. The centromere inactivation is clonally inherited, providing a new
example of epigenetic chromosome imprinting and the possibility of genetically dissecting this process. The involvement of
telomere-related sequences in centromere function is discussed.
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| Biosis |
2000.337332 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Chromosoma |
| Title |
Chromosoma |
| Authors |
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| Volume range |
1- |
| Year range |
1939- |
| Page range |
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| Publisher |
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| Place of publication |
Berlin |
| Language of publication |
English |
| ISBN/ISSN |
0009-5915 |
| CODEN |
CHROAU |
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Data from Reference
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| Aberrations (11)
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| Genes (1)
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