Reference Report

Reference
Citation	Bruckner, K., Perez, L., Clausen, H., Cohen, S. (2000). Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406(6794): 411--415. (Export to RIS)
FlyBase ID	FBrf0129748
Publication Type	Research paper
PubMed ID	10935637
PubMed Abstract	Ligands that are capable of activating Notch family receptors are broadly expressed in animal development, but their activity is tightly regulated to allow formation of tissue boundaries. Members of the fringe gene family have been implicated in limiting Notch activation during boundary formation, but the mechanism of Fringe function has not been determined. Here we present evidence that Fringe acts in the Golgi as a glycosyltransferase enzyme that modifies the epidermal growth factor (EGF) modules of Notch and alters the ability of Notch to bind its ligand Delta. Fringe catalyses the addition of N-acetylglucosamine to fucose, which is consistent with a role in the elongation of O-linked fucose O-glycosylation that is associated with EGF repeats. We suggest that cell-type-specific modification of glycosylation may provide a general mechanism to regulate ligand-receptor interactions in vivo.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (12)
	Dl^{MtnA.T:Hsap\ALPP} fng^{MtnA.T:Hsap\GALNT3,T:Hsap\MYC} fng^{MtnA.T:Hsap\MYC} fng^{NNN.MtnA.T:Hsap\MYC} fng^{NNN.Scer\UAS.T:Hsap\MYC} fng^{Scer\UAS.B.T:Hsap\MYC} fng^{Scer\UAS.T:Hsap\GALNT3,T:Hsap\MYC} N^{MtnA.T:Hsap\ALPP} N^{MtnA.T:Rnor\CD2} Scer\GAL4^ptc-559.1 Ser^{MtnA.T:Hsap\ALPP} w^+mC
Constructs (3)
	P{UAS-fng.GT.myc} P{UAS-fng.MYC.B} P{UAS-fng.NNN.myc}
Genes (10)
	Dl fng N Scer\GAL4 Ser T:Hsap\ALPP T:Hsap\GALNT3 T:Hsap\MYC T:Rnor\CD2 w
Insertions (1)
	P{GawB}ptc^559.1