Reference Report

Reference
Citation	Conley, C.A., Silburn, R., Singer, M.A., Ralston, A., Rohwer-Nutter, D., Olson, D.J., Gelbart, W., Blair, S.S. (2000). Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila. Development 127(18): 3947--3959. (Export to RIS)
FlyBase ID	FBrf0129774
Publication Type	Research paper
PubMed ID	10952893
PubMed Abstract	The BMP-like signaling mediated by the ligands Dpp and Gbb is required to reinforce the development of most veins in the Drosophila wing. However, the formation of the cross veins is especially sensitive to reductions in BMP-like signaling. We show here that the formation of the definitive cross veins occurs after the initial specification of the longitudinal veins in a process that requires localized BMP-like activity. Since Dpp and Gbb levels are not detectably higher in the early phases of cross vein development, other factors apparently account for this localized activity. Our evidence suggests that the product of the crossveinless 2 gene is a novel member of the BMP-like signaling pathway required to potentiate Gbb of Dpp signaling in the cross veins. crossveinless 2 is expressed at higher levels in the developing cross veins and is necessary for local BMP-like activity. The Crossveinless 2 protein contains a putative signal or transmembrane sequence, and a partial Von Willebrand Factor D domain similar to those known to regulate the formation of intramolecular and intermolecular bonds. It also contains five cysteine-rich domains, similar to the cysteine-rich domains found in Chordin, Short Gastrulation and Procollagen that are known to bind BMP-like ligands. These features strongly suggest that Crossveinless 2 acts extracelluarly or in the secretory pathway to directly potentiate Dpp or Gbb signaling.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(2R)Pu-D17 In(2L)dpp^d6
Alleles (20)
	aos^rJ472 cv-2¹ cv-2^225-3 cv-2^EP1103 cv-2^k03511 cv-2^unspecified dpp¹⁰⁶³⁸ dpp^d6 Ecol\lacZ^aos-rJ472 Ecol\lacZ^cv-2-225-3 Ecol\lacZ^rho-AA69 Ecol\lacZ^tkv-P906 gbb⁴ rho^AA69 Scer\GAL4^ap-md544 Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 sog^Scer\UAS.cYa tmx¹ wg^en11
Constructs (1)
	P{UAS-sog.Y}
Genes (20)
	Acox57D-d Acox57D-p aos ase bs CG9822 CG10795 cv-2 dpp Ecol\lacZ EfSec gbb Mad rho rl Scer\GAL4 sog tkv tmx wg
Insertions (12)
	P{A92}rho^AA69 P{en1}wg^en11 P{en2.4-GAL4}e16E P{EP}cv-2^EP1103 P{GawB}ap^md544 P{GawB}ptc^559.1 P{lacW}cv-2^225-3 P{lacW}cv-2^k03511 P{PZ}aos^rJ472 P{PZ}dpp¹⁰⁶³⁸ P{PZ}tkv^P906 P{PZ}tmx¹