Reference Report

Reference
Citation	Gildea, J.J., Lopez, R., Shearn, A. (2000). A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. Genetics 156(2): 645--663. (Export to RIS)
FlyBase ID	FBrf0129826
Publication Type	Research paper
External Crossreferences
PubMed ID	11014813
PubMed Abstract	The proteins encoded by two groups of conserved genes, the Polycomb and trithorax groups, have been proposed to maintain, at the level of chromatin structure, the expression pattern of homeotic genes during Drosophila development. To identify new members of the trithorax group, we screened a collection of deficiencies for intergenic noncomplementation with a mutation in ash1, a trithorax group gene. Five of the noncomplementing deletions uncover genes previously classified as members of the Polycomb group. This evidence suggests that there are actually three groups of genes that maintain the expression pattern of homeotic genes during Drosophila development. The products of the third group appear to be required to maintain chromatin in both transcriptionally inactive and active states. Six of the noncomplementing deficiencies uncover previously unidentified trithorax group genes. One of these deficiencies removes 25D2-3 to 26B2-5. Within this region, there are two, allelic, lethal P-insertion mutations that identify one of these new trithorax group genes. The gene has been called little imaginal discs based on the phenotype of mutant larvae. The protein encoded by the little imaginal discs gene is the Drosophila homologue of human retinoblastoma binding protein 2.
BIOSIS ID	2000.503800
Zoological Record ID
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Editors
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (34)
	Df(1)C52 Df(2L)2802 Df(2L)cl-h1 Df(2L)cl-h3 Df(2L)cl-h4 Df(2L)E110 Df(2L)GpdhA Df(2L)Mdh Df(2R)CX1 Df(2R)en30 Df(2R)en-A Df(2R)eve Df(2R)Jp1 Df(2R)M41A4 Df(2R)M60E Df(2R)or-BR6 Df(2R)Pu-D17 Df(2R)trix Df(2R)vg-C Df(2R)vw Df(2R)X58-7 Df(3L)Ar14-8 Df(3L)brm11 Df(3L)lxd6 Df(3L)Pc Df(3L)vin6 Df(3L)vin7 Df(3R)by62 Df(3R)e-N19 Df(3R)M-Kx1 Df(3R)P115 Df(3R)red1 Df(3R)Scr Df(3R)XTA1
Alleles (51)
	ash1⁴ ash1¹⁷ ash1²² Asx³ Asx¹³ Asx^XF23 brm² cype⁰³⁷⁷¹ E(Pc)¹ E(Pc)² E(z)⁵ esc⁵ esc⁶ esc⁹ esc¹⁰ esc²¹ l(2)04884⁰⁴⁸⁸⁴ Lam⁰⁴⁶⁴³ lid¹⁰⁴²⁴ lid^k06801 lid^unspecified mxc¹ mxc^G48 mxc^M1 Pc³ Pcl⁷ ph-d⁵⁰³ pho^b Psc¹ Psc^Arp1 Sam-S¹ Sce^D1 Scm^D1 Scm^M56 Scm^Suz302 Su(z)2¹ Su(z)2^Arp1 Su(z)3¹ Su(z)4¹ Su(z)6¹ Su(z)7¹ Su(z)12¹ sxc¹ sxc⁴ sxc⁵ Trl^R85 trx² trx^B11 trx^E2 w^unspecified z^unspecified
Genes (31)
	ash1 Asx brm cype E(Pc) E(z) esc hyd l(2)04884 Lam lid mxc Pc Pcl ph-d pho Psc Sam-S Sce Scm Su(z)2 Su(z)3 Su(z)4 Su(z)6 Su(z)7 Su(z)12 sxc Trl trx w z
Insertions (2)
	P{lacW}lid^k06801 P{PZ}lid¹⁰⁴²⁴