Reference Report

Reference
Citation	Guichard, A., Roark, M., Ronshaugen, M., Bier, E. (2000). brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev. Biol. 226(2): 255--266. (Export to RIS)
FlyBase ID	FBrf0129841
Publication Type	Research paper
PubMed ID	11023685
PubMed Abstract	The Drosophila rhomboid (rho) gene participates in localized activation of EGF-receptor signaling in various developmental settings. The Rhomboid protein has been proposed to promote presentation and/or processing of the membrane-bound Spitz (mSpi) EGF-related ligand to generate an active diffusible form of the ligand. Here, we report on a new rhomboid-related gene identified by sequence similarity searching that we have named brother of rhomboid (brho). In contrast to rho, which is expressed in complex patterns during many stages of development, brho appears to be expressed only during oogenesis. brho transcripts are present in early oocytes and abut posterior follicle cells which exhibit high levels of MAPK activation. brho, like rho, collaborates with Star to promote signaling through the EGF-R/MAPK pathway, and genetic evidence indicates that Brho can activate both the mSpi and the Grk precursor EGF ligands in the wing. We propose that endogenous brho may activate the oocyte-specific Gurken ligand and thereby participate in defining posterior cell fates in the early follicular epithelium.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (9)
	Egfr^{DN.Scer\UAS.cBa} grk^Scer\UAS.cQa rho^Scer\UAS.cBa S^Scer\UAS.cGb S^X155 Scer\GAL4^Bx-MS1096 Scer\GAL4^CY2 spi^Scer\UAS.cSa stet^Scer\UAS.cGa
Constructs (6)
	P{UAS-Egfr.DN.B} P{UAS-grk.Q} P{UAS-rho-2} P{UAS-spi.m} P{UAS-Star.G} P{UAS-ve.B}
Genes (11)
	Egfr grk rho rho-4 rho-5 rho-6 ru S Scer\GAL4 spi stet
Insertions (2)
	P{GawB}Bx^MS1096 P{GawB}CY2