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Citation
Lagueux, M., Perrodou, E., Levashina, E.A., Capovilla, M., Hoffmann, J.A. (2000). Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants of Drosophila.  Proc. Natl. Acad. Sci. U.S.A. 97(21): 11427--11432.
FlyBase ID
FBrf0129919
Publication Type
Research paper
Abstract

We show that Drosophila expresses four genes encoding proteins with significant similarities with the thiolester-containing proteins of the complement C3/alpha(2)-macroglobulin superfamily. The genes are transcribed at a low level during all stages of development, and their expression is markedly up-regulated after an immune challenge. For one of these genes, which is predominantly expressed in the larval fat body, we observe a constitutive expression in gain-of-function mutants of the Janus kinase (JAK) hop and a reduced inducibility in loss-of-function hop mutants. We also observe a constitutive expression in gain-of-function Toll mutants. We discuss the possible roles of these novel complement-like proteins in the Drosophila host defense.

PubMed ID
PubMed Central ID
PMC17216 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (6)
    Genes (9)