Reference Report

Reference
Citation	Lee, C.Y., Wendel, D.P., Reid, P., Lam, G., Thummel, C.S., Baehrecke, E.H. (2000). E93 directs steroid-triggered programmed cell death in Drosophila. Mol. Cell 6(2): 433--443. (Export to RIS)
FlyBase ID	FBrf0129927
Publication Type	Research paper
PubMed ID	10983989
PubMed Abstract	Steroid hormones coordinate multiple cellular changes, yet the mechanisms by which these systemic signals are refined into stage- and tissue-specific responses remain poorly understood. Here we show that the Drosophila E93 gene determines the nature of a steroid-induced biological response. E93 mutants possess larval salivary glands that fail to undergo steroid-triggered programmed cell death, and E93 is expressed in cells immediately before the onset of death. E93 protein is bound to the sites of steroid-regulated and cell death genes on polytene chromosomes, and the expression of these genes is defective in E93 mutants. Furthermore, expression of E93 is sufficient to induce programmed cell death. We propose that the steroid induction of E93 determines a programmed cell death response during development.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Aberrations (2)
	Df(3R)93F^x2 Df(3R)e-BS2
Alleles (6)
	Eip93F¹ Eip93F² Eip93F³ Eip93F^Scer\UAS.cLa Scer\GAL4^fkh.PH Scer\GAL4^vg.PM
Constructs (3)
	P{fkh-GAL4.H} P{GAL4-vg.M} P{UAS-Eip93F.L}
Genes (12)
	Ark br crq EcR Eip74EF Eip75B Eip93F ftz-f1 Nc rpr Scer\GAL4 W