Reference Report

Reference
Citation	Nolo, R., Abbott, L.A., Bellen, H.J. (2000). Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell 102(3): 349--362. (Export to RIS)
FlyBase ID	FBrf0129996
Publication Type	Research paper
PubMed ID	10975525
PubMed Abstract	The senseless (sens) gene is required for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS) of Drosophila. Sens is a nuclear protein with four Zn fingers that is expressed and required in the sensory organ precursors (SOP) for proper proneural gene expression. Ectopic expression of Sens in many ectodermal cells causes induction of PNS external sensory organ formation and is able to recreate an ectopic proneural field. Hence, sens is both necessary and sufficient for PNS development. Our data indicate that proneural genes activate sens expression. Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs.
DOI
Related Publication(s)
Review	Paper alert. van Roessel, 2000, Curr. Opin. Genet. Dev. 10(6): 587 [FBrf0133196]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (6)
	Df(1)sc10-1 Df(1)sc-B57 Df(2L)J27 Df(3L)Ly Df(3L)S122804 In(1)y^3PLsc^8R
Alleles (27)
	ato¹ ato^Scer\UAS.cJa da¹ E(spl)m8-HLH^Scer\UAS.cTa Ecol\lacZ^arm.PV Ecol\lacZ^E(spl).2.61 Ecol\lacZ^m4.510P Ecol\lacZ^neur-A101 Ecol\lacZ^nrm-A37 l(3)neo19¹ sc^Scer\UAS.cHa Scer\GAL4^ap-md544 Scer\GAL4^dpp.blk1 sens^+t11 sens^E1 sens^E2 sens^E53 sens^E54 sens^E58 sens^E69 sens^I235 sens^Ly-1 sens^M256 sens^Scer\UAS.cNa sens^SX67 sens^unspecified w^+mC
Constructs (9)
	P{arm-lacZ.V} P{E(spl)-2.61} P{GAL4-dpp.blk1} P{m4-lacZ} P{sens^+t11} P{UAS-ato.J} P{UAS-E(spl).T} P{UAS-sc.USC} P{UAS-sens.N}
Genes (18)
	amos ase ato cpo ct da dap Dl E(spl)m8-HLH Ecol\lacZ futsch grim l(3)neo19 pros sc Scer\GAL4 sens w
Insertions (5)
	P{A92}nrm^A37 P{GawB}ap^md544 P{hsneo}l(3)neo19¹ P{lacW}S122804 P{lArB}neur^A101