Reference Report

Reference
Citation	Pichaud, F., Casares, F. (2000). homothorax and iroquois-C genes are required for the establishment of territories within the developing eye disc. Mech. Dev. 96(1): 15--25. (Export to RIS)
FlyBase ID	FBrf0130024
Publication Type	Research paper
PubMed ID	10940621
PubMed Abstract	In Drosophila the eye-antennal disc gives rise to most adult structures of the fly's head. Yet the molecular basis for its regionalization during development is poorly understood. Here we show that homothorax is required early during development for normal eye development and is necessary for the formation of the ventral head capsule. In the ventral region of the disc only, homothorax and wingless are involved in a positive feedback loop necessary to restrict eye formation. homothorax is able to prevent the initiation and progression of the morphogenetic furrow without inducing wingless, which points to homothorax as a key negative regulator of eye development. In addition, we show that the iroquois-complex genes are required for dorsal head development antagonizing the function of homothorax in this region of the disc.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (2)
	Df(3L)iro-DFM1 Df(3L)iro-DFM3
Alleles (16)
	ara^DFM1 ara^DFM3 Avic\GFP^Scer\UAS.cUa Ecol\lacZ^ara-rF209 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^wg-en11 hth^B2 hth^C1 hth^Meis1-P2 hth^{Scer\UAS.T:Avic\GFP} mirr^DFM3 pan^ΔN.Scer\UAS Scer\GAL4^Act5C.PP Scer\GAL4^arm.PS Scer\GAL4^pnr-MD237 Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}
Constructs (7)
	P{BS3.0} P{GAL4-Act5C(FRT.CD2).P} P{GAL4-Act5C(-FRT).P} P{GAL4-arm.S} P{UAS-GFP.U} P{UAS-GFP-hth} P{UAS-pan.dTCFΔN}
Genes (11)
	ara Avic\GFP caup Ecol\lacZ elav hth mirr pan Scer\GAL4 T:Avic\GFP wg
Insertions (3)
	P{en1}wg^en11 P{GawB}pnr^MD237 P{PZ}ara^rF209