Reference Report

Reference
Citation	Randsholt, N.B., Maschat, F., Santamaria, P. (2000). polyhomeotic controls engrailed expression and the hedgehog signaling pathway in imaginal discs. Mech. Dev. 95(1-2): 89--99. (Export to RIS)
FlyBase ID	FBrf0130036
Publication Type	Research paper
PubMed ID	10906453
PubMed Abstract	Polycomb group (PcG) genes maintain cell identities during development in insects and mammals and their products are required in many developmental pathways. These include limb morphogenesis in Drosophila melanogaster, since PcG genes interact with identity and pattern specifying genes in imaginal discs and clones of polyhomeotic (ph) null cells induce abnormal limb patterning. Such clones are associated with ectopic expression of engrailed, hedgehog, patched, cubitus interruptus and decapentaplegic, in a compartment specific manner. Our results also reveal negative engrailed regulation by ph in both disc compartments: ph silences engrailed in anterior cells and maintains the level of engrailed expression in posterior ones. We suggest that PcG targets are not exclusively regulated by an on/off mechanism, but that the PcG also exerts negative transcriptional control on active genes.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Dp(1;2;Y)w⁺
Alleles (27)
	Asx^XF23 ci^W E(z)⁶¹ Ecol\lacZ^ci.7.1 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^en-Xho25 Ecol\lacZ^hh-P30 Ecol\lacZ^ptc-H84 esc^r4 hh^Mrt inv^W mxc^G46 Pc¹⁶ Pcl¹⁵ ph-d⁴⁰¹ ph-d⁵⁰⁵ ph-d^+tSa pho^b ph-p⁴⁰⁹ ph-p⁴¹⁰ ph-p⁵⁰⁵ ph-p^lac+2 Psc¹ Psc^Arp1 Sce¹ Scm^D1 sxc¹
Constructs (3)
	P{7.1-ci} P{BS3.0} P{ph-d^+tSa}
Genes (19)
	Asx ci E(z) Ecol\lacZ en esc hh inv mxc Pc Pcl ph-d pho ph-p Psc ptc Sce Scm sxc
Insertions (3)
	P{A92}ptc^H84 P{en-lacZ(Xho)}en^Xho25 P{PZ}hh^P30