Reference Report

Reference
Citation	Rorth, P., Szabo, K., Texido, G. (2000). The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation. Mol. Cell 6(1): 23--30. (Export to RIS)
FlyBase ID	FBrf0130050
Publication Type	Research paper
PubMed ID	10949024
PubMed Abstract	The C/EBP transcription factor, Slbo, is required for migration of border cells during Drosophila oogenesis. Unexpectedly, we find that neither increase nor decrease of Slbo activity is tolerated in border cells. Correct protein level is in part ensured by cell type-specific regulated turnover of Slbo protein. Through genetic screening, we identify two genes that are involved in this regulation. The Ubp64 ubiquitin hydrolase acts as a stabilizer of Slbo protein. A novel gene, tribbles, is a negative regulator of slbo in vivo. Tribbles acts by specifically targeting Slbo for rapid degradation via ubiquitination.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell
Title	Molecular Cell
Publication Year	1997-
ISBN/ISSN	1097-2765 1097-4164
Data from Reference
Aberrations (1)
	Df(3L)ri-79c
Alleles (23)
	Ecol\lacZ^slbo-01310 Hsap\UBB^{MtnA.T:Zzzz\His6} Jra^cRa Nle^{MtnA.T:Ivir\HA1} Scer\GAL4^hs.2sev Scer\GAL4^slbo.2.6 Scer\GAL4^vg.PM slbo⁰¹³¹⁰ slbo^hs.PRa slbo^hs.PRb slbo^{LZmut.Scer\UAS} slbo^{MtnA.T:Ivir\HA1} slbo^ry8ex2d slbo^Scer\UAS.cRa slbo^Scer\UAS.cRb slbo^unspecified Src64B^Scer\UAS.cCa trbl^EP1119 trbl^EP3519 trbl^{MtnA.T:Uuuu\T7} trbl^Scer\UAS.cMa Ubp64E^EP3584 Ubp64E^Scer\UAS.cRa
Constructs (11)
	P{GAL4-Hsp70.sev} P{GAL4-slbo.2.6} P{GAL4-vg.M} P{hs-slbo.Ra} P{hs-slbo.Rb} P{UAS-slbo.LZmut} P{UAS-slbo.Ra} P{UAS-slbo.Rb} P{UAS-Src64B.C} P{UAS-trbl.M} P{UAS-Ubp64E.R}
Genes (14)
	Ecol\lacZ faf Fas3 Hsap\UBB Jra Nle Scer\GAL4 slbo Src64B T:Ivir\HA1 T:Uuuu\T7 T:Zzzz\His6 trbl Ubp64E
Insertions (4)
	P{EP}trbl^EP3519 P{EP}Ubp64E^EP3584 P{UAS-Ubp64E.R}1 P{UAS-Ubp64E.R}2