FB2025_01 , released February 20, 2025
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Reference
Citation
Ruiz-Gomez, M., Coutts, N., Price, A., Taylor, M.V., Bate, M. (2000). Drosophila dumbfounded: a myoblast attractant essential for fusion.  Cell 102(2): 189--198.
FlyBase ID
FBrf0130056
Publication Type
Research paper
Abstract
Aggregation and fusion of myoblasts to form myotubes is essential for myogenesis in many organisms. In Drosophila the formation of syncytial myotubes is seeded by founder myoblasts. Founders fuse with clusters of fusion-competent myoblasts. Here we identify the gene dumbfounded (duf) and show that it is required for myoblast aggregation and fusion. duf encodes a member of the immunoglobulin superfamily of proteins that is an attractant for fusion-competent myoblasts. It is expressed by founder cells and serves to attract clusters of myoblasts from which myotubes form by fusion.
PubMed ID
10943839
PubMed Central ID
DOI
10.1016/s0092-8674(00)00024-6
Related Publication(s)
Review

Paper alert.
Jones, 2000, Curr. Opin. Genet. Dev. 10(5): 462 [FBrf0131033]

Erratum

Erratum. Drosophila Dumbfounded: A myoblast attractant essential for fusion.
Ruiz-Gomez et al., 2001, Cell 104(1): following 172 [FBrf0133279]

Note

Mergers and acquisitions: unequal partnerships in Drosophila myoblast fusion.
Frasch and Leptin, 2000, Cell 102(2): 127--129 [FBrf0129817]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (9)
    Alleles (9)
    Genes (14)
    Insertions (3)
    Experimental Tools (1)
    Transgenic Constructs (4)