Reference Report

Reference
Citation	Scanga, S.E., Ruel, L., Binari, R.C., Snow, B., Stambolic, V., Bouchard, D., Peters, M., Calvieri, B., Mak, T.W., Woodgett, J.R., Manoukian, A.S. (2000). The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19(35): 3971--3977. (Export to RIS)
FlyBase ID	FBrf0130065
Publication Type	Research paper
PubMed ID	10962553
PubMed Abstract	Akt (or PKB) is an oncogene involved in the regulation of cell survival. Akt is regulated by phosphatidylinositol 3-OH kinase (PI3'K) signaling and has shown to be hyperactivated through the loss of the PTEN tumor suppressor. In Drosophila, insulin signaling as studied using the Drosophila IRS-4 homolog (Chico) has been shown to be a crucial regulator of cell size. We have studied Drosophila Akt (Dakt1) and have shown that it is also involved in the regulation of cell size. Furthermore we have performed genetic epistasis tests to demonstrate that in Drosophila, PI3'K, PTEN and Akt comprise a signaling cassette that is utilized during multiple stages of development. In addition, we show that this signaling cassette is also involved in the regulation of cell survival during embryogenesis. This study therefore establishes the evolutionary conservation of this signaling pathway in Drosophila. Oncogene (2000) 19, 3971 - 3977.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Oncogene
Title	Oncogene
Publication Year	1987-
ISBN/ISSN	0950-9232
Data from Reference
Alleles (8)
	Akt1¹ Akt1⁰⁴²²⁶ Akt1^hs.PS Pi3K92E^{D954A.Scer\UAS.T:Hsap\MYC} Pten^Scer\UAS.cSa Scer\GAL4^ey.PH Scer\GAL4^hs.PB Scer\GAL4^unspecified
Constructs (6)
	P{Dp110^D954A} P{GAL4} P{GAL4-ey.H} P{GAL4-Hsp70.PB} P{hs-Akt1.S} P{UAS-Pten.S}
Genes (4)
	Akt1 Pi3K92E Pten Scer\GAL4
Insertions (1)
	P{PZ}Akt1⁰⁴²²⁶