Reference Report

Reference
Citation	Toba, G., Aigaki, T. (2000). Disruption of the microsomal glutathione S-transferase-like gene reduces life span of Drosophila melanogaster. Gene 253(2): 179--187. (Export to RIS)
FlyBase ID	FBrf0130115
Publication Type	Research paper
PubMed ID	10940555
PubMed Abstract	Microsomal glutathione S-transferase-I (MGST-I) has been thought to be important for protecting the cell from oxidative damages and/or xenobiotics. We have previously identified the Microsomal glutathione S-transferase-like (Mgstl) gene, a Drosophila homologue of human MGST-I. To investigate the function of the enzyme using Drosophila as a model system, we examined the expression pattern of Mgstl during development, and generated loss-of-function mutants to assess its in-vivo function. Mgstl was expressed in all developmental stages. It is expressed ubiquitously with the highest expression in the larval fat body, an insect organ thought to be functionally corresponding to mammalian liver, while relatively low in the central nervous system. This tissue distribution is consistent with that of MGST-I in humans or Rats. Mgstl null mutants generated from a P element insertion line showed no obvious defects in morphology, indicating that it is not essential for the development. However, their life span was significantly reduced compared to control flies, suggesting that the MGSTL protein is involved in processes somehow contributing to aging. We found an Mgstl pseudogene, which is apparently derived through the reverse transcription of Mgstl mRNA and subsequent integration into the genome.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Gene
Title	Gene
Publication Year	1976-
ISBN/ISSN	0378-1119
Data from Reference
Aberrations (2)
	Df(1)16-3-22 Df(1)mal3
Alleles (5)
	Mgstl^E8 Mgstl^E41 Mgstl^E54 Mgstl^E65 Mgstl^GS1051
Genes (2)
	CR12628 Mgstl
Insertions (1)
	P{GSV1}Mgstl^GS1051