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Reference Report
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| Citation | Volkner, M., Lenz-Bohme, B., Betz, H., Schmitt, B. (2000). Novel CNS glutamate receptor subunit genes of Drosophila melanogaster. J. Neurochem. 75(5): 1791--1799. (Export to RIS) | ||
| FlyBase ID | FBrf0130145 | ||
| Publication Type | Research paper | ||
| PubMed ID | 11032867 | ||
| PubMed Abstract | We report the identification and characterization of two genes from Drosophila melanogaster that encode novel ionotropic glutamate receptor proteins, named DGluR-IB and DNMDAR-II, and that are located on chromosome 3L, region 67AB, and the X chromosome, position 2B, respectively. The DGluR-IB full-length cDNA was isolated from Drosophila embryonic and head libraries. The encoded protein of 1,095 amino acids displays high sequence identity (73%) to DGluR-IA. The DNMDAR-II gene was identified by sequence-homology searches in databases. The deduced protein shows moderate sequence identity (29-31%) to the mouse NMDAR2A-D receptor subunits. Whole-mount in situ hybridization on embryos revealed DGluR-IB and DNMDAR-II transcripts in the CNS. Immunofluorescence analysis of the adult fly brain indicates that the DGluR-IB protein is expressed in neurons implicated in the regulation of the circadian clock. | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | J. Neurochem. | ||
| Title | Journal of Neurochemistry | ||
| Publication Year | 1956- | ||
| ISBN/ISSN | 0022-3042 | ||
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Data from Reference
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| Genes (4)
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