Reference Report

Reference
Citation	Wolf, C., Schuh, R. (2000). Single mesodermal cells guide outgrowth of ectodermal tubular structures in Drosophila. Genes Dev. 14(17): 2140--2145. (Export to RIS)
FlyBase ID	FBrf0130172
Publication Type	Research paper
PubMed ID	10970878
PubMed Abstract	The Drosophila tracheal system, a tubular network, is formed from isolated ectodermal metameres by guided branch outgrowth and branch fusion. Branch outgrowth is triggered by the localized and transient activity of Branchless (Bnl/dFGF). Here, we report the discovery of a mesodermal cell that links the leading cells of outgrowing main branches 2.5 hr before they fuse. This bridge-cell serves as an essential guidance post and needs Hunchback (Hb) activity to exert its function. The bridge-cell provides cues acting in concert with Bnl/dFGF signaling to mediate directed branch outgrowth that ultimately leads to position-specific branch fusion.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (16)
	Avic\GFP^{Scer\UAS.T:Ecol\lacZ,T:SV40\nls2} BacA\p35^Scer\UAS.cHa bnl⁰⁰⁸⁵⁷ bnl^Scer\UAS.cSa btl^H82Δ3 Ecol\lacZ^esg-6 Ecol\lacZ^trh-1-eve-1 hb⁸ hb¹⁵ hb^Scer\UAS.cWa Scer\GAL4^12.1 Scer\GAL4^Act5C.PP Scer\GAL4^btl.PS Scer\GAL4^twi.PG trh¹ vvl^dfr-E82
Constructs (7)
	P{GAL4-Act5C(-FRT).P} P{GAL4-btl.S} P{GAL4-twi.G} P{UAS-bnl.S} P{UAS-GFP::lacZ.nls} P{UAS-hb.W} P{UAS-p35.H}
Genes (15)
	Avic\GFP BacA\p35 bnl btl crb Ecol\lacZ esg hb salm Scer\GAL4 stg T:Ecol\lacZ T:SV40\nls2 trh vvl
Insertions (3)
	P{enG}6 P{ET-L}trh-1-eve-1 P{GAL4}12.1
Transcripts (3)
	Ecol\lacZ^esg-6RA Ecol\lacZ^trh-1-eve-1RA Scer\GAL4^btl.PSRA