|Citation||Wolf, C., Schuh, R. (2000). Single mesodermal cells guide outgrowth of ectodermal tubular structures in Drosophila. Genes Dev. 14(17): 2140--2145. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||The Drosophila tracheal system, a tubular network, is formed from isolated ectodermal metameres by guided branch outgrowth and branch fusion. Branch outgrowth is triggered by the localized and transient activity of Branchless (Bnl/dFGF). Here, we report the discovery of a mesodermal cell that links the leading cells of outgrowing main branches 2.5 hr before they fuse. This bridge-cell serves as an essential guidance post and needs Hunchback (Hb) activity to exert its function. The bridge-cell provides cues acting in concert with Bnl/dFGF signaling to mediate directed branch outgrowth that ultimately leads to position-specific branch fusion.|
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|Language of Publication||English|
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|Also Published As|
|Title||Genes & Development|
|Data from Reference|