Reference Report

Reference
Citation	Yu, H.H., Huang, A.S., Kolodkin, A.L. (2000). Semaphorin-1a acts in concert with the cell adhesion molecules fasciclin II and connectin to regulate axon fasciculation in Drosophila. Genetics 156(2): 723--731. (Export to RIS)
FlyBase ID	FBrf0130183
Publication Type	Research paper
PubMed ID	11014819
PubMed Abstract	Semaphorins comprise a large family of phylogenetically conserved secreted and transmembrane glycoproteins, many of which have been implicated in repulsive axon guidance events. The transmembrane semaphorin Sema-1a in Drosophila is expressed on motor axons and is required for the generation of neuromuscular connectivity. Sema-1a can function as an axonal repellent and mediates motor axon defasciculation. Here, by manipulating the levels of Sema-1a and the cell adhesion molecules fasciclin II (Fas II) and connectin (Conn) on motor axons, we provide further evidence that Sema-1a mediates axonal defasciculation events by acting as an axonally localized repellent and that correct motor axon guidance results from a balance between attractive and repulsive guidance cues expressed on motor neurons.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (1)
	Df(3L)Flex14
Alleles (5)
	Con^Fvex238 Fas2^EB112 Fas2^Scer\UAS.cLa Scer\GAL4^elav-C155 Sema-1a^k13702
Constructs (1)
	P{UAS-Fas2.PEST-}
Genes (4)
	Con Fas2 Scer\GAL4 Sema-1a
Insertions (1)
	P{GawB}elav^C155