Reference Report

Reference
Citation	Aderem, A., Ulevitch, R.J. (2000). Toll-like receptors in the induction of the innate immune response. Nature 406(6797): 782--787. (Export to RIS)
FlyBase ID	FBrf0131060
Publication Type	Review
PubMed ID	10963608
PubMed Abstract	The innate immune response is the first line of defence against infectious disease. The principal challenge for the host is to detect the pathogen and mount a rapid defensive response. A group of proteins that comprise the Toll or Toll-like family of receptors perform this role in vertebrate and invertebrate organisms. This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Genes (16)
	18w AttA AttB AttC cact Dif Drs ECSIT ird6 ird8 pll Rel spz Tl Traf4 tub