Reference Report

Reference
Citation	Flores, G.V., Duan, H., Yan, H., Nagaraj, R., Fu, W., Zou, Y., Noll, M., Banerjee, U. (2000). Combinatorial signaling in the specification of unique cell fates. Cell 103(1): 75--85. (Export to RIS)
FlyBase ID	FBrf0131288
Publication Type	Research paper
PubMed ID	11051549
PubMed Abstract	How multifunctional signals combine to specify unique cell fates during pattern formation is not well understood. Here, we demonstrate that together with the transcription factor Lozenge, the nuclear effectors of the EGFR and Notch signaling pathways directly regulate D-Pax2 transcription in cone cells of the Drosophila eye disc. Moreover, the specificity of D-Pax2 expression can be altered upon genetic manipulation of these inputs. Thus, a relatively small number of temporally and spatially controlled signals received by a set of pluripotent cells can create the unique combinations of activated transcription factors required to regulate target genes and ultimately specify distinct cell fates within this group. We expect that similar mechanisms may specify pattern formation in vertebrate developmental systems that involve intercellular communication.
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (50)
	aop^ACT.Scer\UAS aop^e2d aop^pok-x8 Avic\GFP^Scer\UAS.cUa btl::Egfr^{Scer\UAS.T:λ\cI-DD} Dl^B2 Dl^D.Scer\UAS Dl^R7 Ecol\lacZ^{HLHmγ.12xSu(H)bs} Ecol\lacZ^{sv.SME.mETS1,6} Ecol\lacZ^{sv.SME.mETSx6} Ecol\lacZ^sv.SME.mRDx3 Ecol\lacZ^{sv.SME.mSuHx8} Ecol\lacZ^sv.SME Egfr^DN.Scer\UAS Egfr^t1 Egfr^tsla H^Scer\UAS.cGa lz^r1 lz^sev.PF lz^ts1 N^act.sev N^{ECN.Scer\UAS.cGa} N^l1N-ts1 pnt¹²³⁰ pnt^{T151A.Scer\UAS} Scer\FLP1^GMR.PP Scer\GAL4^Act5C.PI Scer\GAL4^GMR.PF Scer\GAL4^lz-gal4 Scer\GAL4^{Scer\FRT.Act5C} sv^+m1 sv^+m2 sv^+m4 sv^+m6 sv^+mFa sv^m3 sv^m5 sv^m7 sv^m8 sv^m9 sv^m10 sv^m11 sv^m12 sv^m13 sv^m14 sv^mRDx3 sv^spa-1 sv^spa-pol T:λ\cI^DD
Constructs (36)
	P{12xSu(H)bs-lacZ} P{Act5C-GAL4} P{AyGAL4} P{GAL4-ninaE.GMR} P{GMR-FLP1.P} P{sev-lz.F} P{sev-N^act} P{spa^+mFa} P{sv^+m1} P{sv^+m2} P{sv^+m4} P{sv^+m6} P{sv^m3} P{sv^m5} P{sv^m7} P{sv^m8} P{sv^m9} P{sv^m10} P{sv^m11} P{sv^m12} P{sv^m13} P{sv^m14} P{sv^mRDx3} P{sv-lacZ.SME.mETS1,6} P{sv-lacZ.SME.mETSx6} P{sv-lacZ.SME.mRDx3} P{sv-lacZ.SME.mSuHx8} P{sv-lacZ.SME} P{UAS-aop.ACT} P{UAS-Dl.DN} P{UAS-Egfr.DN} P{UAS-Egfr.λtop} P{UAS-GFP.U} P{UAS-H.G} P{UAS-N.ECN.G} P{UAS-pnt.P2.T151A}
Genes (17)
	aop Avic\GFP btl::Egfr Dl Ecol\lacZ Egfr elav H lz N pnt rl Scer\FLP1 Scer\GAL4 Su(H) sv T:λ\cI
Insertions (1)
	P{GawB}lz^gal4
Sequence features (3)
	sv_Frag7 sv_Frag8 sv_SME