Reference Report

Reference
Citation	Ghazi, A., Anant, S., VijayRaghavan, K. (2000). Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cues. Development 127(24): 5309--5318. (Export to RIS)
FlyBase ID	FBrf0131298
Publication Type	Research paper
PubMed ID	11076753
PubMed Abstract	Two physiologically distinct types of muscles, the direct and indirect flight muscles, develop from myoblasts associated with the Drosophila wing disc. We show that the direct flight muscles are specified by the expression of Apterous, a Lim homeodomain protein, in groups of myoblasts. This suggests a mechanism of cell-fate specification by labelling groups of fusion competent myoblasts, in contrast to mechanisms in the embryo, where muscle cell fate is specified by single founder myoblasts. In addition, Apterous is expressed in the developing adult epidermal muscle attachment sites. Here, it functions to regulate the expression of stripe, a gene that is an important element of early patterning of muscle fibres, from the epidermis. Our results, which may have broad implications, suggest novel mechanisms of muscle patterning in the adult, in contrast to embryonic myogenesis.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	In(2LR)O
Alleles (15)
	Act88F^{AGH.T:Ecol\lacZ} ap⁴ ap^rK568 ap^Scer\UAS.cOa Avic\GFP^Scer\UAS.cUa Ecol\lacZ^ap.ME15 Ecol\lacZ^ap-rK568 Ecol\lacZ^Mhc.PH Ecol\lacZ^sr-03999 Scer\GAL4¹¹⁵¹ Scer\GAL4^pnr-MD237 Scer\GAL4^sr-md710 sr¹ sr⁰³⁹⁹⁹ sr^G11
Balancers (2)
	CyO CyO-Mhc-lacZ
Constructs (5)
	P{Act88F-lacZ} P{ME15-lacZ} P{Mhc-lacZ.H} P{UAS-ap.O} P{UAS-GFP.U}
Genes (8)
	Act88F ap Avic\GFP Ecol\lacZ Scer\GAL4 sr T:Ecol\lacZ twi
Insertions (6)
	P{GAL4}1151 P{GawB}pnr^MD237 P{GawB}sr^md710 P{Mhc-lacZ.H}CyO P{PZ}ap^rK568 P{PZ}sr⁰³⁹⁹⁹
Transcripts (2)
	Ecol\lacZ^ap.ME15 Scer\GAL4^sr-md710RA