Reference Report

Reference
Citation	Haines, N., van Den Heuvel, M. (2000). A directed mutagenesis screen in Drosophila melanogaster reveals new mutants that influence hedgehog signaling. Genetics 156(4): 1777--1785. (Export to RIS)
FlyBase ID	FBrf0131307
Publication Type	Research paper
PubMed ID	11102373
PubMed Abstract	The Hedgehog signaling pathway has been recognized as essential for patterning processes in development of metazoan animal species. The signaling pathway is, however, not entirely understood. To start to address this problem, we set out to isolate new mutations that influence Hedgehog signaling. We performed a mutagenesis screen for mutations that dominantly suppress Hedgehog overexpression phenotypes in the Drosophila melanogaster wing. We isolated four mutations that influence Hedgehog signaling. These were analyzed in the amenable wing system using genetic and molecular techniques. One of these four mutations affects the stability of the Hedgehog expression domain boundary, also known as the organizer in the developing wing. Another mutation affects a possible Hedgehog autoregulation mechanism, which stabilizes the same boundary.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (4)
	Df(2L)J39 Df(2R)or-BR11 Df(2R)PC4 Df(3L)vin7
Alleles (17)
	ci^Scer\UAS.cAa dpp^Scer\UAS.cSa Drer\shh^Scer\UAS.cIa Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^Scer\UAS.cUa gbb^unspecified hh^Mrt Scer\GAL4^30A Scer\GAL4^34B Scer\GAL4^bs-1348 Su(hh)I^I Su(hh)II^II Su(hh)III^III Su(hh)IV^IV Su(hh)V^V Su(hh)VI^VI Su(hh)VII^VII
Constructs (4)
	P{BS3.0} P{UAS-ci.A} P{UAS-dpp.S} P{UAS-lacZ.U}
Genes (15)
	ci dpp Drer\shh Ecol\lacZ en gbb hh Scer\GAL4 Su(hh)I Su(hh)II Su(hh)III Su(hh)IV Su(hh)V Su(hh)VI Su(hh)VII
Insertions (3)
	P{GAL4}bs¹³⁴⁸ P{GawB}30A P{GawB}34B