Reference Report

Reference
Citation	Pueyo, J.I., Galindo, M.I., Bishop, S.A., Couso, J.P. (2000). Proximal-distal leg development in Drosophila requires the apterous gene and the Lim1 homologue dlim1. Development 127(24): 5391--5402. (Export to RIS)
FlyBase ID	FBrf0131382
Publication Type	Research paper
External Crossreferences
PubMed ID	11076760
PubMed Abstract	Proximal-distal leg development in Drosophila involves a battery of genes expressed and required in specific proximal-distal (PD) domains of the appendage. Here we report the characterisation of a new gene of this type, dlim1, a member of the Lhx family of genes whose proteins contain two Lim domains and a homeodomain. We show that the Lhx gene apterous (ap) is also required for PD leg development, and we study the functional interactions between ap, dlim1 and other PD genes during leg development. Our results show that a regulatory network formed by ap and dlim1 plus the homeobox genes aristaless and Bar specifies distal leg cell fates in Drosophila.
BIOSIS ID	2001.62436
Zoological Record ID
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Editors
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2R)nap1
Alleles (33)
	al^ice al^Scer\UAS.cSa ap^md544 ap^Scer\UAS.cBa ap^UGO35 ap^unspecified B-H2^P058 Chi^{FL.Scer\UAS.T:Hsap\MYC} Chi^g96.1 Chi^g371 Chi^M3 Ecol\lacZ^B-H2-P058 Ecol\lacZ^Lim1-P0092 Lim1^P0092 Lim1^R2.3 Lim1^R6.2 Lim1^R6.3 Lim1^R6.6 Lim1^R8.1 Lim1^R10.6 Lim1^R12.4 Lim1^R16.3 Lim1^R20.2 Lim1^R21.3 Lim1^R32.1 Lim1^R35.2 Lim1^R36.5 Lim1^Scer\UAS.cTb Lim3^Scer\UAS.cTa Scer\GAL4^30A Scer\GAL4^ap-md544 Scer\GAL4^cmk10 Scer\GAL4^dpp.blk1
Constructs (6)
	P{GAL4-dpp.blk1} P{Scer\UAS(-FRT)al.S} P{UAS-ap.B} P{UAS-Chi.FL} P{UAS-Lim1.Th} P{UAS-lim3.T}
Genes (10)
	al ap B-H2 Chi Ecol\lacZ Lim1 Lim3 Scer\GAL4 T:Hsap\MYC tup
Insertions (5)
	P{GAL4}cmk10 P{GawB}30A P{GawB}ap^md544 P{lArB}B-H2^P058 P{lArB}Lim1^P0092